GCHFR Antibody
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中文名稱：GCHFR兔多克隆抗體
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貨號：CSB-PA008753
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規格：￥1090
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其他：
產品詳情
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Uniprot No.：
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基因名：GCHFR
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別名：GCHFR antibody; GFRP antibody; GFRP_HUMAN antibody; GTP cyclohydrolase 1 feedback regulatory protein antibody; GTP cyclohydrolase I feedback regulator antibody; GTP cyclohydrolase I feedback regulatory protein antibody; HsT16933 antibody; MGC138467 antibody; MGC138469 antibody; p35 antibody
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宿主：Rabbit
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反應種屬：Human,Rat
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免疫原：Synthesized peptide derived from the Internal region of Human GFRP.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution IHC 1:100-1:300 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.
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基因功能參考文獻：
- homozygous individuals for the TT haplotype were less likely to respond to the SSRI fluoxetine than to the nortriptyline suggesting a biological process through which GCHFR promoter variants might influence antidepressant response. PMID: 20351752
- Bacterial lipopolysaccharide down-regulates expression of GTP cyclohydrolase I feedback regulatory protein PMID: 11799107
- allosteric regulation of GTPCH-I activity in the cardiovascular system maybe an important mechanism regulating BH4 levels through GTPCH-I feedback regulatory protein signaling PMID: 15649650
- GFRP/GTPCHI axis functions in epidermal keratinocytes and melanocytes in the cytosol and nucleus. PMID: 16778797
- GCH1 mutations in Japanese patients with DYT5 dystonia. In some of them, the GCH1 enzyme activity was proved to be impaired. PMID: 17101830
- The co-expression of GTP cyclohydrolase I (GCHI) with tyrosine hydroxylase (TH) indicates that TH is indeed active in human neurosecretory neurons. PMID: 17135716
- Demonstrate role for GFRP in regulating iNOS-mediated NO synthesis and suggest that the allosteric regulation of GTP-CH1 activity by GFRP may be an important mechanism regulating BH(4) and NO levels in vivo. PMID: 18372436
- crystal structure PMID: 11580249
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亞細胞定位：Nucleus. Nucleus membrane. Cytoplasm, cytosol.
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蛋白家族：GFRP family
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組織特異性：In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level).
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數據庫鏈接：
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