GBP5 Antibody

中文名稱：

GBP5兔多克隆抗體
貨號(hào)：

CSB-PA847203LA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA847203LA01HU at dilution of 1:100
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) GBP5 Polyclonal antibody
Uniprot No.：

Q96PP8
基因名：

GBP5
別名：

GBP 5 antibody; GBP TA antigen antibody; GBP-5 antibody; GBP-TA antigen antibody; GBP5 antibody; GBP5_HUMAN antibody; GTP binding protein 5 antibody; GTP-binding protein 5 antibody; Guanine nucleotide binding protein 5 antibody; Guanine nucleotide-binding protein 5 antibody; Guanylate binding protein 5 antibody; Guanylate-binding protein 5 antibody; UNQ2427/PRO4987 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human, Mouse
免疫原：

Recombinant Human Guanylate-binding protein 5 protein (321-500AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，GBP5 Antibody (CSB-PA847203LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于GBP5 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA847203LB01HU	GBP5 Antibody, HRP conjugated	ELISA
FITC	CSB-PA847203LC01HU	GBP5 Antibody, FITC conjugated
Biotin	CSB-PA847203LD01HU	GBP5 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents. Hydrolyzes GTP, but in contrast to other family members, does not produce GMP.
基因功能參考文獻(xiàn)：
1. GBP5 and KLF2 may be useful as a diagnostic tool for active tuberculosis, also the two-gene set may serve as surrogate biomarkers for monitoring tuberculosis therapy. PMID: 28941629
2. these results reveal that GBP5 inhibited influenza virus replication through the activation of IFN signaling and proinflammatory factors PMID: 28376501
3. Previously reported tetrameric and dimeric species of hGBP-1 and hGBP-5 were unmasked as dimers and monomers, respectively, with their shapes depending on both the bound nucleotide and the ionic strength of the solution. PMID: 28580591
4. Antiviral activity requires Golgi localization of GBP5, but not its GTPase activity. PMID: 26996307
5. GZMA, GBP5 and CD64 genes show promise as a rapid diagnostic markers separating tuberculosis from other pulmonary diseases. PMID: 26025597
6. The in vivo localization of GBP-5 at the Golgi apparatus is regulated by isoprenylation and dimerization. PMID: 21151871
7. analysis of guanylate binding protein 5 and a tumor-specific truncated splice variant PMID: 20180847
8. Eight of nine melanoma cell lines expressed GBP-5a/b and four of nine additionally low levels of GBP-5ta. PMID: 15175044
9. 3 genes were upregulated in patients with chronic EBV infection: guanylate binding protein 1, tumor necrosis factor-induced protein 6, and guanylate binding protein 5; they may be associated with the inflammatory reaction or with cell proliferation. PMID: 18260761
10. GBP5 is constitutively localized in the Golgi apparatus of endothelial cells. PMID: 17266443
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亞細(xì)胞定位：

Cytoplasm. Golgi apparatus membrane; Lipid-anchor.
蛋白家族：

TRAFAC class dynamin-like GTPase superfamily, GB1/RHD3-type GTPase family, GB1 subfamily
組織特異性：

Expressed in peripheral blood monocytes (at protein level).
數(shù)據(jù)庫(kù)鏈接：

HGNC: 19895

OMIM: 611467

KEGG: hsa:115362

STRING: 9606.ENSP00000340396

UniGene: Hs.513726

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