GBA3 Antibody
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中文名稱(chēng)：GBA3兔多克隆抗體
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貨號(hào)：CSB-PA884446ESR1HU
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規(guī)格：￥440
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圖片：
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Western blot
All lanes: GBA3 antibody at 10µg/ml
Lane 1: Hela whole cell lysate
Lane 2: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 54, 19 kDa
Observed band size: 54 kDa -
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA884446ESR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA884446ESR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA884446ESR1HU at dilution of 1:100
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱(chēng)：Rabbit anti-Homo sapiens (Human) GBA3 Polyclonal antibody
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Uniprot No.：
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基因名：GBA3
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別名：CBG antibody; CBGL1 antibody; Cytosolic beta glucosidase antibody; Cytosolic beta glucosidase like protein 1 antibody; Cytosolic beta-glucosidase antibody; Cytosolic beta-glucosidase-like protein 1 antibody; GBA3 antibody; GBA3_HUMAN antibody; GLUC antibody; Glucosidase beta acid 3 antibody; Klotho related protein antibody; KLRP antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Cytosolic beta-glucosidase protein (1-162AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類(lèi)型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 IHC 1:20-1:200 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides. Has a significant glucosylceramidase activity in vitro. However, that activity is relatively low and its significance in vivo is not clear. Also able to hydrolyze galactosylceramide/GalCer, glucosylsphingosine/GlcSph and galactosylsphingosine/GalSph. However, the in vivo relevance of these activities is unclear. It can also hydrolyze a broad variety of dietary glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens in vitro and could therefore play a role in the metabolism of xenobiotics. Could also play a role in the catabolism of cytosolic sialyl free N-glycans.
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基因功能參考文獻(xiàn)：
- cytosolic GBA3 is likely involved in the catabolism of cytosolic sialyl free N-glycans, possibly by stabilizing the activity of the NEU2 protein PMID: 26193330
- No correlation was observed between GBA3 1368A/T haplotypes and severity of type 1 Gaucher disease manifestation PMID: 20728381
- The positioning of a substrate molecule (quercetin-4'-glucoside) by homology modelling revealed that hydrophobic interactions dominate the binding of the aglycone moiety. PMID: 17555766
- The crystal structure of a covalent intermediate of the KLrP mutant E165Q, in which glucose was covalently bound to a nucleophile, Glu(373), is reported. PMID: 18662675
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亞細(xì)胞定位：Cytoplasm, cytosol.
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蛋白家族：Glycosyl hydrolase 1 family, Klotho subfamily
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組織特異性：Present in small intestine (at protein level). Expressed in liver, small intestine, colon, spleen and kidney. Down-regulated in renal cell carcinomas and hepatocellular carcinomas.
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數(shù)據(jù)庫(kù)鏈接：
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