GATAD2B Antibody, FITC conjugated

說明書

中文名稱：

GATAD2B兔多克隆抗體, FITC偶聯
貨號：

CSB-PA823905LC01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) GATAD2B Polyclonal antibody
Uniprot No.：

Q8WXI9
基因名：

GATAD2B
別名：

FLJ37346 antibody; GATA zinc finger domain containing 2B antibody; GATA zinc finger domain containing protein 2B antibody; GATA zinc finger domain-containing protein 2B antibody; GATAD2B antibody; KIAA1150 antibody; MGC138257 antibody; MGC138285 antibody; mKIAA1150 antibody; p66/p68 antibody; P66B_HUMAN antibody; P66beta antibody; RGD1308533 antibody; transcription repressor p66 beta component of the MeCP1 complex antibody; Transcriptional repressor p66 beta antibody; Transcriptional repressor p66-beta antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Transcriptional repressor p66-beta protein (58-146AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus. May play a role in synapse development.
基因功能參考文獻：
1. GATAD2B interacts with C-MYC to enhance KRAS driven tumor growth. PMID: 30013058
2. This data suggests that 1q21.3 microdeletion is a recurrent microdeletion syndrome with distinguishable phenotypes, and loss of function of GATAD2B is the major contributor of the characteristic facies and ID. PMID: 28211977
3. findings suggest that GATAD2B serves as an important mediator of progesterone-progesterone receptor suppression of proinflammatory and contractile genes during pregnancy; decreased GATAD2B expression near term may contribute to the decline in progesterone receptor function, leading to labor PMID: 28576827
4. This is the first report of GATAD2B in Chinese ID patients. Our findings will broaden the spectrum of GATAD2B mutations and facilitate genetic diagnosis and counseling. PMID: 28077840
5. p66beta might be important for the regulation of LOX in the nucleus. PMID: 25118846
6. Detailed clinical description showed that all four individuals with a GATAD2B aberration had a distinctive phenotype with childhood hypotonia, severe intellectual disability. PMID: 23644463
7. identification as potent transcriptional repressors interacting with MBD2 and MBD3 PMID: 12183469
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相關疾?。?/div>
Mental retardation, autosomal dominant 18 (MRD18)
亞細胞定位：

Nucleus speckle.
組織特異性：

Widely expressed.
數據庫鏈接：

HGNC: 30778

OMIM: 614998

KEGG: hsa:57459

STRING: 9606.ENSP00000357644

UniGene: Hs.4779

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