GAS1 Antibody
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中文名稱：GAS1兔多克隆抗體
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貨號：CSB-PA009264LA01HU
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規格：￥440
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圖片：
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Western Blot
Positive WB detected in: SH-SY5Y whole cell lysate, 293 whole cell lysate
All lanes: GAS1 antibody at 3.2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 36 kDa
Observed band size: 36 kDa -
Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA009264LA01HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA009264LA01HU at dilution of 1:100 -
Immunofluorescence staining of Hela cells with CSB-PA009264LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) GAS1 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：GAS-1 antibody; Gas1 antibody; GAS1_HUMAN antibody; Growth arrest-specific protein 1 antibody; Growth-arrest-specific protein 1 precursor antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Growth arrest-specific protein 1 protein (248-318AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，GAS1 Antibody (CSB-PA009264LA01HU)，的標記方式是Non-conjugated。對于GAS1 Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC, IF
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 IHC 1:20-1:200 IF 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells.
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基因功能參考文獻：
- Studies establish Gas1 as a negative regulator in colorectal cancer. PMID: 27401611
- These results demonstrated that miR-184 and the GAS1/Akt pathway may be a potential therapeutic target for intervertebral disc degeneration. PMID: 26805687
- WT1 modulates Akt/JNK signaling pathway mediated autophagy by controlling the expression of growth arrest-specific 1 (Gas1). PMID: 27453337
- Downregulation of GAS1 is associated with clear cell renal cell carcinoma. PMID: 28184927
- the synergistic effect of Gas1 inhibition and GDNF against glutamate-induced cell injury in human SH-SY5Y neuroblastoma cells, is reported. PMID: 26215053
- solutions structure and biophysical characterization of the multifaceted signalling effector protein growth arrest specific-1 PMID: 25888394
- This review summarizes the structure of Gas1 and molecular mechanism of action during embryonic development and cellular functions. PMID: 25429664
- GAS1 is a novel endogenous inhibitor of glomerular mesangial cell proliferation. PMID: 23254899
- Growth arrest-specific gene 1 is downregulated and inhibits tumor growth in gastric cancer. PMID: 22846196
- GAS1 induced the activity of caspase-3 and resulting in apoptosis of the cells. PMID: 22311470
- Interference of endoplasmic reticulum to Golgi transport increased immature amyloid beta protein precursor accumulation upon Gas1 expression in lipid raft fractions. PMID: 21971401
- we demonstrate that sequence variants in GAS1 can impair its physical interaction with SHH, suggesting a decrease in the SHH downstream signaling cascade as a pathogenic mechanism of disease. PMID: 21842183
- Gas1 is a novel APP-interacting protein involved in the control of APP maturation and processing. PMID: 21357679
- Growth arrest-specific gene 1 contributes to predicting metastasis or recurrence in stage II and III colorectal cancer. PMID: 21111449
- GAS1 could be considered a candidate locus for one of the types of human holoprosencephaly. PMID: 20583177
- Gas1 is related to the GDNF alpha receptors and regulates Ret signaling PMID: 16551639
- This review considers the possible involvement of GAS1 in genetic diseases, stem cell renewal, and cancer growth through its cooperative activity with Hedgehog (HH) growth factor and the HH receptor. PMID: 17726382
- Gas1 is a molecule involved in cell arrest that can induce apoptosis when over-expressed in different cell lines. PMID: 18394855
- Gas1 has all the expected properties of a melanoma tumor suppressor: suppression of metastasis in a spontaneous metastasis assay, promotion of apoptosis following dissemination of cells to secondary sites, and down-regulation in human melanoma metastasis. PMID: 18981472
- Results present evidence demonstrating that Gas1 exerts its effects inhibiting cell growth and inducing apoptosis of glioma cells in the absence of Shh. PMID: 19460624
- Results suggest that GAS1 might be a target to overcome multidrug resistance and provide a novel approach to identifying candidate genes that suppress chemoresistance of gastric cancers. PMID: 19638344
- GAS1 is preferentially expressed by human bulge cells, compared to differentiated hair follicle keratinocytes PMID: 20050020
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亞細胞定位：Cell membrane; Lipid-anchor, GPI-anchor.
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數據庫鏈接：
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