GALR2 Antibody, Biotin conjugated
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中文名稱：GALR2兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA009224LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) GALR2 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：GALR2; GALNR2; Galanin receptor type 2; GAL2-R; GALR-2
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Galanin receptor type 2 protein (282-387AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).
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基因功能參考文獻：
- Study provides evidence that GAL and GALR1/2 genes were identified as aberrantly methylated in head and neck squamous cell carcinoma. PMID: 27685843
- GAL and its receptors, GALR1 and GALR2, play a role in head and neck squamous cell carcinoma tumorigenesis PMID: 26572146
- The G protein-coupled receptor GALR2 promotes angiogenesis in head and neck cancer PMID: 24568968
- In HEp-2 cells, GALR2-mediated apoptosis was caspase-independent. PMID: 24168112
- Activation of GalR2 leads to elevation of intracellular Ca(2+) due to Ca(2+) efflux from endoplasmic reticulum through IP3R sequentially opening BK alpha channels. PMID: 24602615
- The expression of GALR2 mRNA is lost in head and neck squamous cell carcinoma as a consequence of DNA methylation.Silencing of the GALR2 gene by methylation may be a critical event in head and neck squamous cell carcinoma. PMID: 24122450
- galanin receptor 2 promotes cell proliferation and survival, and promotes tumor growth, consistent with an oncogenic role for GALR2 in squamous cell carcinoma of the head and neck PMID: 21345369
- Elevated expression of galanin receptors in childhood neuroblastic tumors PMID: 11867941
- study indicates that a high level of GalR2 galanin receptor expression is able to inhibit cell proliferation and induce apoptosis in neuroblastoma cells PMID: 14592962
- There was no effect of GALR2 on alcoholism risk. PMID: 17083333
- point to GalR2 as a possible target for therapeuthic interventions in pheochromocytoma PMID: 18272487
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亞細胞定位：Cell membrane; Multi-pass membrane protein.
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蛋白家族：G-protein coupled receptor 1 family
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組織特異性：Expressed abundantly within the central nervous system in both hypothalamus and hippocampus. In peripheral tissues, the strongest expression was observed in heart, kidney, liver, and small intestine.
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數據庫鏈接：
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