GALNT14 Antibody

中文名稱：

GALNT14兔多克隆抗體
貨號：

CSB-PA836212LA01HU
規格：

￥440
圖片：
Western blot
All lanes: GALNT14 antibody at 2µg/ml
Lane 1: Rat gonad tissue
Lane 2: Mouse kidney tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 65, 61, 62 kDa
Observed band size: 65 kDa

Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA836212LA01HU at dilution of 1:100
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) GALNT14 Polyclonal antibody
Uniprot No.：

Q96FL9
基因名：

GALNT14
別名：

GalNAc T14 antibody; GalNAc-T14 antibody; Galnt14 antibody; GLT14_HUMAN antibody; Polypeptide GalNAc transferase 14 antibody; Polypeptide N acetylgalactosaminyltransferase 14 antibody; Polypeptide N-acetylgalactosaminyltransferase 14 antibody; pp GaNTase 14 antibody; pp-GaNTase 14 antibody; Protein UDP acetylgalactosaminyltransferase 14 antibody; Protein-UDP acetylgalactosaminyltransferase 14 antibody; UDP GalNAc:polypeptide N acetylgalactosaminyltransferase 14 antibody; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 14 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse, Rat
免疫原：

Recombinant Human Polypeptide N-acetylgalactosaminyltransferase 14 protein (1-552AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，GALNT14 Antibody (CSB-PA836212LA01HU)，的標記方式是Non-conjugated。對于GALNT14 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA836212LB01HU	GALNT14 Antibody, HRP conjugated	ELISA
FITC	CSB-PA836212LC01HU	GALNT14 Antibody, FITC conjugated
Biotin	CSB-PA836212LD01HU	GALNT14 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney.
基因功能參考文獻：
1. Silencing of GALNT14 in osterix-overexpressed cells restored the decreased chemosensitivity. Conversely, overexpression of GALNT14 in osterix-knockdown cells abrogated the increased chemosensitivity in breast cancer cells. PMID: 29227978
2. The analysis showed that the "TT" genotype was associated with unfavorable overall survival (OS, P = 0.009). PMID: 27124048
3. miR-125a functions as tumor suppressor in ovarian cancer by targeting GALNT14. PMID: 27133078
4. GALNT14 genotypes were significantly associated with clinical outcomes of transcatheter arterial chemoembolization. PMID: 26871639
5. Expression of GalNAc-T14 or HOXB9 was strongly correlated with reduced recurrence-free survival in lung adenocarcinomas. PMID: 26544896
6. Recurrence of mutation suggests GALNT14 as a novel gene potentially involved in neuroblastoma predisposition. PMID: 26309160
7. GALNT14 stimulates MMP-2 expression. PMID: 24962947
8. GALN14 genotype (rs9679162) was an effective predictor for therapeutic outcome in advanced hepatocellular carcinoma (HCC) patients treated by FMP chemotherapy. PMID: 23959947
9. Studies demonstrate that IGFBP-3 and GalNAc-T14 are colocalized in MCF-7 cells, and confirmed the interaction between IGFBP-3 and GalNAc-T14; these results reveal a minimal region of GalNAc-T14 that was sufficiently bound to the full-length IGFBP-3. PMID: 22441125
10. Results provide evidence that GalNAc-T14 may be a potential biomarker for breast cancer by immunohistochemistry. PMID: 20356418
11. GALNT14 and FUT3/6 H-scores were significantly higher in non-small cell lung cancer cell lines sensitive to dulanermin and drozitumab versus resistant cell lines PMID: 20179215
12. cloning and characterization; results provide evidence that pp-GalNAc-T14 is a new member of the pp-GalNAc-T family and suggest that it may be involved in the O-glycosylation in kidney PMID: 12507512
13. The role of GalNAc-T14 as an intracellular mediator of the effects of IGFBP-3 need to be verified in future studies. PMID: 17434446
14. GALNT14 may be involved in regulating the apoptotic action of IGFBP-3. PMID: 19805900
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亞細胞定位：

Golgi apparatus membrane; Single-pass type II membrane protein.
蛋白家族：

Glycosyltransferase 2 family, GalNAc-T subfamily
組織特異性：

Detected in renal tubules (at protein level). Highly expressed in fetal and adult kidney. Widely expressed at low level. Weakly expressed in whole brain, cerebellum, thymus, lung, mammary gland, liver, stomach, small intestine, colon, pancreas, spleen, bl
數據庫鏈接：

HGNC: 22946

OMIM: 608225

KEGG: hsa:79623

STRING: 9606.ENSP00000288988

UniGene: Hs.468058

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