GALK1 Antibody
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中文名稱：GALK1兔多克隆抗體
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貨號：CSB-PA009198GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：GALK1
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別名：EC 2.7.1.6 antibody; epididymis secretory protein Li 19 antibody; Galactokinase 1 antibody; Galactokinase antibody; Galactose kinase antibody; GALK 1 antibody; GALK antibody; GALK1 antibody; GALK1_HUMAN antibody; GK1 antibody; GLK antibody; GLK1 antibody; HEL-S-19 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human GALK1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Major enzyme for galactose metabolism.
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基因功能參考文獻：
- Mutation in the GALK gene is associated with mental disorders in galactosemia. PMID: 28672748
- The GALK1 gene was included in this interval and direct sequencing. PMID: 24211322
- Data indicate taht the interactions between galactokinase (GALK) and its potential inhibitors by molecular dynamics simulations. PMID: 23517731
- The study highlighted the importance of GALK gene analysis in diagnosis of galactosemia in Indian population. PMID: 22632133
- A possible mechanism for the unfolding caused by the Pro(28)Thr point mutation of human galactokinase. PMID: 21264483
- Pathogenic mutations in GALK1 that are responsible for autosomal recessive congenital cataracts in consanguineous Pakistani families, are reported. PMID: 20405025
- 2 new GALK1 mutations near the ATP-binding site were found in a homozygotic Turkish immigrant: S142I and G148C. PMID: 11978883
- a functional analysis of disease-causing mutations in this enzyme PMID: 12694189
- In this northern Italian population age-related cataract does not appear to be associated with GALK1 alleles. PMID: 12942049
- structure and function of galactokinase, and role in type II galactosemia [review] PMID: 15526155
- active site geometry of this enzyme upon which to more fully understand the consequences of the those mutations known to give rise to Type II galactosemia. PMID: 15590630
- Mutations in GALK1 resulted in reduction of GALK activity and caused GALK deficiency. PMID: 17517531
- These results suggest that the elevated GALK1 activity resulted from enhanced gene expression, due to nucleotide variation within GALK1 promoter PMID: 19309526
- Structure of the human enzyme complexed with MgAMP.PNP and galactose PMID: 15590630
- The disease-causing point mutations in the human enzyme are mapped onto the structure of the protein from Pyrococcus furiosus and speculations made about the structural consequences. PMID: 15003454
- 2-deoxy-D-galactose is a substrate for this enzyme. D-glucose, D-fucose, L-arabinose and N-acetyl-D-galactosamine are not. Mutations H44A, H44I, E43G/H44I are insoluble, D46A is inactive, E43G has reduced activity and E43A has wild-type activity. PMID: 14596685
- Has ordered ternary complex mechanism with ATP being the first substrate to bind. PMID: 12694189
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相關疾病：Galactosemia II (GALCT2)
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蛋白家族：GHMP kinase family, GalK subfamily
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數據庫鏈接：
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