GABRA6 Antibody, Biotin conjugated

說明書

中文名稱：

GABRA6兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA623078LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) GABRA6 Polyclonal antibody
Uniprot No.：

Q16445
基因名：

GABRA6
別名：

GABA A antibody; GABA A Receptor alpha 6 polypeptide antibody; GABA A receptor alpha 6 antibody; GABA A receptor subunit alpha 6 antibody; GABA subunit A receptor alpha 6 antibody; GABA(A) receptor subunit alpha-6 antibody; GABRA 6 antibody; GABRA6 antibody; Gamma aminobutyric acid A receptor alpha 6 antibody; Gamma aminobutyric acid GABA A receptor alpha 6 antibody; Gamma aminobutyric acid receptor subunit alpha 6 antibody; Gamma-aminobutyric acid receptor subunit alpha-6 antibody; GBRA6_HUMAN antibody; MGC116903 antibody; MGC116904 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Gamma-aminobutyric acid receptor subunit alpha-6 protein (20-242AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
基因功能參考文獻：
1. TMEM132D, COMT and GABRA6 gene polymorphisms may influence susceptibility to panic disorder(PD) and major depressive disorder(MDD)in Japanese adults; these variants may increase vulnerability to PD by modulating oligodendrocytes and GABA and dopaminergic functions in related brain regions, altering neuronal processing of anxiety-related emotional signals PMID: 25974322
2. NOS3, GABRA6, child abuse, neighborhood crime Gene x Gene, Environment x Environment, and Gene x Environment interactions are associated with different patterns of respiratory sinus arrhythmia reactivity. PMID: 26535938
3. The gene-gene interaction at two loci involving GABRA6 and Synapsin II revealed a significant association for development of idiopathic generalized epilepsy. PMID: 25088614
4. genetic association study in Chinese Han population: Data suggest an SNP in GABRA6 (rs3219151) is associated with decreased predisposition to schizophrenia via alteration of miroRNA binding to target in 3-prime-untranslated region of GABRA6 mRNA. PMID: 23332465
5. GABRA6 mutation, R46W, was identified as a susceptibility gene that may contribute to the pathogenesis of childhood absence epilepsy and cause neuronal disinhibition and increase in seizures via a reduction of alphabetagamma and alphabetadelta receptor function and expression PMID: 21930603
6. Part of the interindividual differences observed for anxiety traits measured by the Harm Avoidance dimension could be explained by the GABRA6 gene variability. PMID: 21902679
7. significant involvement of alpha (GABRA6) and beta (GABRB2) subunits of GABA(A) receptor in epilepsy susceptibility in north Indian population PMID: 21420396
8. studies have found prefrontal cortical GABA(A) receptor alpha subunit alterations in schizophrenia PMID: 20100621
9. These findings support a role for the serotonin transporter and GABA(A) alpha6 subunit in depression-related traits. PMID: 14744464
10. The T1521C polymorphism in the GABRA6 gene is associated with specific personality characteristics as well as a marked attenuation in hormonal and blood pressure responses to psychological stress. PMID: 15197399
11. GABRA6 expression is regulated by NFI in cerebellar granule neurons PMID: 15466411
12. Findings support a role for GABRA6 (Pro385Ser) in perceived parenting. PMID: 16402352
13. Polymorphism not associated with panic disorder. PMID: 17167337
14. Chinese patients with certain psychiatric characteristics and GABRA6 heterozygosity are probably predisposed to functional heartburn PMID: 17295876
15. The T allele of the 1519T>C GABA(A)alpha6 gene may be one of the modulating factors associated with changes in craving for alcohol and food during treatment of patients with alcohol dependence. PMID: 18616664
16. Significant matching effects were found for polymorphisms at the DRD2, GABRA6 and GABRB2 gene. In addition, a trend was found for the OPRM1 polymorphism. PMID: 19523047
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亞細胞定位：

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
蛋白家族：

Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRA6 sub-subfamily
數據庫鏈接：

HGNC: 4080

OMIM: 137143

KEGG: hsa:2559

STRING: 9606.ENSP00000274545

UniGene: Hs.90791

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