Phospho-mFLNc (S2237) Antibody
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中文名稱(chēng)：磷酸化-mFLNc (S2237)兔多克隆抗體
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貨號(hào)：CSB-PA837745XA01phMO
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規(guī)格：￥440
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：
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別名：Filamin-C, FLN-C, ABP-280-like protein, ABP-L, Actin-binding-like protein, Filamin-2, Gamma-filamin, Flnc, Abpl, Fln2
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反應(yīng)種屬：Mus musculus (Mouse)
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免疫原：Synthesized peptide derived from Mouse FLNc around the phosphorylation site of S2237.
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免疫原種屬：Mus musculus (Mouse)
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標(biāo)記方式：Non-conjugated
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克隆類(lèi)型：Polyclonal
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抗體亞型：IgG
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純化方式：Affinity-purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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問(wèn)答及客戶(hù)評(píng)論
■ 常見(jiàn)問(wèn)題解答
Q:
我想要以下兩種抗體:在S2237位點(diǎn)磷酸化的小鼠FLNc (mFLNc)，在S2236位點(diǎn)磷酸化的人類(lèi)FLNc (hFLNc)，這些是相同磷酸化殘基的小鼠和人類(lèi)同源物。
A:
我們可以提供兔多克隆抗體生產(chǎn)，以產(chǎn)生針對(duì)S2237位點(diǎn)磷酸化的小鼠FLNc (mFLNc)和S2236位點(diǎn)磷酸化的人FLNc (hFLNc)的抗體。
我們的標(biāo)準(zhǔn)兔多克隆抗體生產(chǎn)方案的交付成果和保證包括:
質(zhì)量保證:
1．高效液相色譜法多肽純度＞85%
2．抗體純度＞90% SDS-PAGE證實(shí);
3.抗體滴度 ELISA確認(rèn):1:64,000;
交付物:
1．200ug肽- KHL/BSA偶聯(lián)物。
2．1ml免疫前血清。
3．兔多克隆抗體1mg，經(jīng)肽親和層析純化。
靶點(diǎn)詳情
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功能：Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers.
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基因功能參考文獻(xiàn)：
- HSPB7 is essential for maintaining muscle integrity, which is achieved through its interaction with FLNC PMID: 26929074
- The data of this study presented here provide further support that FLNC, a muscle-specific protein, could be a potential novel player in FTD pathogenesis. PMID: 26555887
- Aciculin interacts with filamin C and Xin and is essential for myofibril assembly. PMID: 24963132
- KY, IGFN1 and FLNC are part of a Z-band associated protein complex likely to provide structural support to the skeletal muscle sarcomere. PMID: 20206623
- filamin C may function in signal transduction or cellular migration of the myogenic progenitor cell population PMID: 15910244
- These data provide the first evidence that FLNc has a crucial role in muscle development and maintenance of muscle structural integrity and suggest the presence of a TRIO-FLNc-dependent pathway in maintaining proper myotube structure. PMID: 16914736
- MuRF3 has an essential role in maintaining cardiac integrity and function after acute myocardial infarction and turnover of FHL2 and gamma-filamin contributes to this cardioprotective function of MuRF3 PMID: 17360532
- Cbl-associated protein provides another link between the myofibril cytoskeleton and the plasma membrane of muscle cells, and it may play a dynamic role in the regulation and maintenance of muscle structural integrity PMID: 17898075
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亞細(xì)胞定位：Cytoplasm. Membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line.
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蛋白家族：Filamin family
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數(shù)據(jù)庫(kù)鏈接：
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