FOXRED1 Antibody
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中文名稱：FOXRED1兔多克隆抗體
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貨號：CSB-PA822192ESR1HU
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規格：￥440
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圖片：
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Western blot
All lanes: FOXRED1 antibody at 5.28µg/ml + A549 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 54, 31, 53 kDa
Observed band size: 54 kDa -
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA822192ESR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA822192ESR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) FOXRED1 Polyclonal antibody
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Uniprot No.：
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基因名：FOXRED1
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別名：FOXRED1; FP634; FAD-dependent oxidoreductase domain-containing protein 1
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human FAD-dependent oxidoreductase domain-containing protein 1 protein (307-486AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:1000-1:5000 IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly.
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基因功能參考文獻：
- Results show that depletion of FOXRED1 in myoblasts results in decreased levels of fully assembled complexes I and II. FOXRED1 associates with the ND1-containing subcomplexes of ~370 kDa and ~620 kDa and that FOXRED1 activity is required for the formation of a 550-kDa subcomplex of complex I. PMID: 27215383
- Loss of FOXRED1, coupled with protein, choline and/or folate-deficient diets results in the depletion of glutathione, the dysregulation of nitric oxide metabolism and the peroxynitrite-mediated inactivation of complex I. PMID: 26235939
- A structural model of FOXRED1 reveals a large substrate-binding cavity and a putative oxygen-binding site. PMID: 25765152
- FOXRED1 is a crucial component in the productive assembly of respiratory chain complex I and that mutations in FOXRED1 leading to partial loss of function cause defects in complex I biogenesis. PMID: 25678554
- Mutations in FOXRED1 are associated with complex I deficiency. PMID: 20818383
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相關疾病：Mitochondrial complex I deficiency (MT-C1D)
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亞細胞定位：Mitochondrion inner membrane; Single-pass membrane protein.
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數據庫鏈接：
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