FOXF2 Antibody, Biotin conjugated

說明書

中文名稱：

FOXF2兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA623661LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) FOXF2 Polyclonal antibody
Uniprot No.：

Q12947
基因名：

FOXF2
別名：

FOXF2 antibody; FKHL6 antibody; FREAC2Forkhead box protein F2 antibody; Forkhead-related activator 2 antibody; FREAC-2 antibody; Forkhead-related protein FKHL6 antibody; Forkhead-related transcription factor 2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Forkhead box protein F2 protein (226-364AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Probable transcription activator for a number of lung-specific genes. Mediates up-regulation of the E3 ligase IRF2BPL and drives ubiquitination and degradation of CTNNB1.
基因功能參考文獻：
1. FOXF2 rs1711972 AA genotype is associated with poor response to therapy in Non-small Cell Lung Cancer. PMID: 28766235
2. miR130a can regulate FOXF2 and function as an oncogene in colorectal cancer. PMID: 28849155
3. FOXF2 deficiency induced mesenchymal-epithelial transition (MET) in Huh7 cell which might facilitate the colonization of circulating tumor cells and the formation of metastasis. PMID: 28582850
4. Cox proportional hazards regression model was used to evaluate the predictive value of FOXF2 mRNA level in non-small cell lung cancer patients PMID: 27487137
5. FOXF2 has a dual role in breast tumorigenesis and functions as either a tumor suppressor or an oncogene depending on the breast tumor subtype. PMID: 27377963
6. MAZ/FOXF2 axis can promote the proliferation of basal like breast cancer cells and suppress disease progression. PMID: 28577976
7. direct targeting of Foxf2 by Shh signaling drives cranial neural crest cell mesenchyme proliferation during upper lip morphogenesis, and disruption of this sequence results in cleft lip. PMID: 28506991
8. Common variants near FOXF2 that are associated with increased stroke susceptibility. PMID: 27068588
9. No correlation was found between FOXF2 promoter methylation and other clinic pathological parameters (age, gender, differentiation, lymph node metastasis, stage, cutting edge, vascular invasion, smoking behavior, and drinking history) in esophageal squamous cell carcinoma. PMID: 28222662
10. Loss of FOXF2 Expression is associated with Hepatocellular Carcinoma. PMID: 25824262
11. results provided statistical evidence of linkage and association between FOXF2 and nonsyndromic cleft lip with or without cleft palate. PMID: 26278207
12. The miR-200 family and the miR-183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers. PMID: 25798833
13. MiR-182-induced downregulation of FoxF2. PMID: 25738520
14. Subtype-specific expression and function of FOXF2 in breast cancer cells are regulated through the combined effects of DNA methylation and SP1 transcriptional regulation. PMID: 26070560
15. Foxf2 inactivation in adults resulted in blood-brain barrier breakdown, endothelial thickening, and increased trans-endothelial vesicular transport PMID: 26120030
16. decreased FOXF2 expression indicates the early-onset metastasis and poor prognosis for patients with histological grade II and triple-negative breast cancer. PMID: 23620774
17. MicroRNA-182-5p promotes cell invasion and proliferation by down regulating FOXF2, RECK and MTSS1 genes in human prostate cancer. PMID: 23383207
18. 2 unique DNA sequence alterations could have affected FOXF2 on the mRNA or protein level thus contributing to the observed disturbances in genital and palate development PMID: 19276632
19. The distinct expression pattern of FOXF2 in the prostate, its effect on expression of signaling, and its opposing role in the TGFbeta3 pathway, suggests a role for FOXF2 in prostate homeostasis and stroma-epithelial interactions PMID: 19562724
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亞細胞定位：

Nucleus.
組織特異性：

Lung and placenta. Predominantly expressed in gastrointestinal tract including stomach.
數據庫鏈接：

HGNC: 3810

OMIM: 603250

KEGG: hsa:2295

STRING: 9606.ENSP00000259806

UniGene: Hs.484423

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