FNBP1L Antibody

說明書

中文名稱：

FNBP1L兔多克隆抗體
貨號：

CSB-PA008763GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q5T0N5
基因名：

FNBP1L
別名：

C1orf39 antibody; FBP1L_HUMAN antibody; FNBP 1L antibody; fnbp1l antibody; Formin binding protein 1 like antibody; Formin-binding protein 1-like antibody; TOCA 1 antibody; Toca-1 antibody; TOCA1 antibody; Transducer of Cdc42 dependent actin assembly 1 antibody; Transducer of Cdc42 dependent actin assembly protein 1 antibody; Transducer of Cdc42-dependent actin assembly protein 1 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human FNBP1L
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

0.1M NaHCO3,0.1M Glycine, 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens.
基因功能參考文獻：
1. This suggests that TOCA1 binding to Cdc42 is an early step in the Cdc42-dependent pathways that govern actin dynamics, and the differential binding affinities of the effectors facilitate a handover from TOCA1 to N-WASP, which can then drive recruitment of the actin-modifying machinery. PMID: 27129201
2. Loss of p53 tumor suppressor function in breast cancers leads to upregulation of Toca-1, and results in enhanced risk of developing metastatic disease. PMID: 25547174
3. GWAS results show that the aggregate effects of common SNPs explain 22-46% of phenotypic variation in childhood intelligence in the three largest cohorts; FNBP1L was also significantly associated with childhood intelligence PMID: 23358156
4. findings suggest that Toca-1 functions at an early step in the dissemination of metastatic breast tumor cells; taken together, results identify Toca-1 as a proinvasive protein in breast adenocarcinoma PMID: 22824798
5. Toca-1 knockdown cells also display a significant defect in EGF-induced motility and invasiveness. PMID: 21062739
6. Cdc42 may influence endocytic membrane trafficking by regulating the formation and activity of the Toca-1/N-WASP complex. PMID: 20730103
7. Toca-1 promotes actin nucleation by activating the N-WASP-WIP/CR16 complex, the predominant form of N-WASP in cells. PMID: 15260990
8. a vesicle trafficking regulator Toca-1 regulates different aspects of neuronal morphology from N-WASP PMID: 16885158
9. We show that actin tail initiation by S. flexneri requires Toca-1 for the conversion of N-WASP from a closed inactive conformation to an open active one. PMID: 18191793
10. the Toca-1-N-WASP complex can link filopodial formation to endocytosis PMID: 19213734
11. FNBP1L appears dispensable for other forms of autophagy induced by serum starvation or rapamycin PMID: 19342671
12. Human FNBP1L binds the autophagy protein Atg3 and is required for autophagy of Salmonella Typhimurium in epithelial cells PMID: 19342671
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亞細胞定位：

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cytoplasmic vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
蛋白家族：

FNBP1 family
數據庫鏈接：

HGNC: 20851

OMIM: 608848

KEGG: hsa:54874

STRING: 9606.ENSP00000271234

UniGene: Hs.134060

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