FMOD Antibody, FITC conjugated
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中文名稱：FMOD兔多克隆抗體, FITC偶聯(lián)
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貨號：CSB-PA008755LC01HU
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規(guī)格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) FMOD Polyclonal antibody
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Uniprot No.：
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基因名：FMOD
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別名：Collagen binding 59 kDa protein antibody; Collagen-binding 59 kDa protein antibody; Fibromodulin antibody; Fibromodulin precursor antibody; Fibromodulin proteoglycan antibody; FM antibody; FMOD antibody; FMOD_HUMAN antibody; Keratan sulfate proteoglycan fibromodulin antibody; KSPG fibromodulin antibody; SLRR2E antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Fibromodulin protein (18-89AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis.
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基因功能參考文獻：
- The results of luciferase reporter assay and methylation-specific PCR (MSP) demonstrated that GDNF facilitated the demethylation of the FMOD promoter. PMID: 30176167
- crystal structures at ~2.2A resolution of human fibromodulin and chondroadherin. PMID: 28215822
- we found that secreted FMOD as an important regulator of glioma cell migration downstream of TGF-beta1 pathway and forms a potential basis for therapeutic intervention in GBM. PMID: 27212030
- The small leucine rich proteoglycan fibromodulin is overexpressed in human prostate epithelial cancer cell lines in culture and human prostate cancer tissue. PMID: 26600400
- expression levels distinguish chronic lymphocytic leukemia B cells from normal B lymphocytes PMID: 26318878
- The data suggest a fibromodulin-modulated collagen cross-linking mechanism where fibromodulin binds to a specific part of the collagen domain and also forms a complex with lysyl oxidase, targeting the enzyme toward specific cross-linking sites. PMID: 26893379
- fibromodulin is involved in the inflammatory processes that characterize atherosclerotic plaque vulnerability PMID: 26125412
- The results suggest that regions within FMOD is associated with ACL injury susceptibility and that genetic sequence variability within genes encoding proteoglycans may potentially modulate the ligament fibril properties. PMID: 24552666
- Melanocyte-secreted factor FMOD is a key regulator of angiogenesis. PMID: 24355922
- Associations between higher fibomodulin gene expression and risk factors in chronic lymphocytic leukemia. PMID: 22099931
- Hepatic fibromodulin activates hepatic stellate cells and promotes collagen I deposition, which leads to liver fibrosis. PMID: 22138190
- lumican and fibromodulin display different behaviors and that lumican may promote regeneration of the TMJ after degeneration and deformation induced by IL-1 beta. PMID: 22073367
- study shows (1) a detailed description of ectopic ossification (EO) formed by Bgn, Fmod or combined depletion, (2) the role of exercise in modulating EO and (3) that Bgn and Fmod are critical in controlling motor function. PMID: 19422643
- Fibromodulin is shown for the first time to be naturally processed and presented as a tumor-associated antigen in primary chronic lymphocytic leukemia cells, enabling the expansion of autologous tumor-specific T cells. PMID: 15471955
- Fibromodulin has a role in progression of B-cell chronic lymphocytic leukemia and mantle cell lymphoma PMID: 15741214
- fibromodulin activates the classical pathway of complement by directly binding C1q PMID: 16046396
- complement control protein 6-8 is able to interact with DNA and necrotic cells, but in contrast the His-384 allotype binds these ligands more strongly than the Tyr-384 variant PMID: 17293598
- The collagen-binding Glu-353 and Lys-355 residues in fibromodulin are exposed on the exterior of the beta-sheet-loop structure of the leucine-rich repeat, which resembles the location of interacting residues in other leucine-rich repeat proteins. PMID: 17623650
- Fibromodulin gene is constantly expressed in human epidermal keratinocytes. PMID: 18448071
- Specific decorin and fibromodulin core protein fragments in degenerate meniscus and/or human articular cartilage may be of value as biomarkers of disease. PMID: 18620607
- CD200 blockade was further shown to stimulate antigen-specific T cell responses towards the CLL-associated antigen fibromodulin PMID: 18838168
- Homologous sequence in lumican and fibromodulin leucine-rich repeat 5-7 competes for collagen binding. PMID: 19008226
- Ultraviolet B and A irradiation induce FMOD expression in fibroblasts in vitro. PMID: 19041686
- differentially expressed in mesenchymal stromal cell subset with reduced differentiation potential PMID: 19242838
- tyrosine sulfate-rich domains of the LRR proteins fibromodulin and osteoadherin bind motifs of basic clusters in a variety of heparin-binding proteins, including bioactive factors PMID: 19700767
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亞細胞定位：Secreted, extracellular space, extracellular matrix.
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蛋白家族：Small leucine-rich proteoglycan (SLRP) family, SLRP class II subfamily
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