FKBP10 Antibody
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中文名稱：FKBP10兔多克隆抗體
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貨號(hào)：CSB-PA822180LA01HU
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規(guī)格：￥440
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圖片：
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IHC image of CSB-PA822180LA01HU diluted at 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) FKBP10 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：FKBP10 antibody; FKBP65 antibody; PSEC0056Peptidyl-prolyl cis-trans isomerase FKBP10 antibody; PPIase FKBP10 antibody; EC 5.2.1.8 antibody; 65 kDa FK506-binding protein antibody; 65 kDa FKBP antibody; FKBP-65 antibody; FK506-binding protein 10 antibody; FKBP-10 antibody; Immunophilin FKBP65 antibody; Rotamase antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP10 protein (459-579AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
本頁(yè)面中的產(chǎn)品，F(xiàn)KBP10 Antibody (CSB-PA822180LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于FKBP10 Antibody，我們還提供其他標(biāo)記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:200-1:500 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：PPIases accelerate the folding of proteins during protein synthesis.
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基因功能參考文獻(xiàn)：
- FKBP10 interacts with collagen VI and deficiency of FKBP10 reduces lung fibroblast migration by down-regulation of collage VI synthesis. PMID: 29673351
- Data found novel mutations of the SERPINF1 and FKBP10 genes in Chinese families with autosomal recessive osteogenesis imperfecta PMID: 29512769
- an endoplasmic reticulum complex of resident chaperones that includes HSP47, FKBP65, and BiP regulating the activity of LH2. PMID: 28177155
- FKBP10 protein is overexpressed in renal cell carcinoma PMID: 27602571
- FKBP65 is linked to pyridinoline cross-linking by specifically mediating the dimerization of LH2. PMID: 27298363
- novel pathogenic mutations of FKBP10 can lead to the extremely rare type XI Osteogenesis imperfecta without contractures, which expands the genotypic spectrum of Osteogenesis imperfecta. PMID: 27762305
- Mutations in FKBP10, localised to chromosome 17q21, have been identified in a patient of Bruck syndrome. Additional cases are also discussed. PMID: 25931047
- A pathogenic change was found in the FKBP10 gene in patients with osteogenesis imperfecta. PMID: 27706701
- findings further extend the body of evidence that supports the importance of FKBP10 gene in the development of skeletal system PMID: 26538303
- Mutations in the HSP47 and FKBP65 produce a moderately severe form of Osteogenesis imperfect. PMID: 25510505
- CTSD, FKBP10, and SLC2A1 are novel genes that participate in the acquisition and maintenance of the adriamycin-resistant phenotype in leukemia cells. PMID: 24467213
- Results imply that FKBP10 mutations affect collagen indirectly, by ablating FKBP65 support for collagen telopeptide hydroxylation by lysyl hydroxylase 2, thus decreasing collagen cross-links in tendon and bone matrix. PMID: 23712425
- Elastin binding protein and FKBP65 modulate the kinetics of self-assembly of tropoelastin in an in vitro system. PMID: 24106871
- FKBP10 depletion enhances glucocerebrosidase proteostasis in Gaucher disease fibroblasts PMID: 23434032
- underexpression of FKBP65 protein is characteristic of high-grade serous carcinomas and this expression profile may be linked to molecular pathways associated with an unfavourable outcome in cancer patients. PMID: 23354471
- FKBP10 acts during procollagen maturation to contribute to molecular stability and post-translational modification of type I procollagen, without which bone mass and quality are abnormal and fractures and contractures result PMID: 22949511
- identified a Palestinian pedigree with moderate and lethal forms of recessive OI caused by mutations in FKBP10 or PPIB, which encode endoplasmic reticulum resident chaperone/isomerases FKBP65 and CyPB, respectively PMID: 22718341
- Homozygosity mapping identified FKBP10 as a candidate gene, and sequencing revealed a base pair exchange that causes a C-terminal premature stop codon in this gene. PMID: 22107750
- Mutations in FKBP10 cause both Bruck syndrome and isolated osteogenesis imperfecta in humans. PMID: 21567934
- The differential expression of FKBP65 indicates a role in ovarian physiology as well as in ovarian tumor development PMID: 21399973
- FKBP10 mutations are a cause of recessive osteogenesis imperfecta and Bruck syndrome. PMID: 20839288
- Mutations in the gene encoding the RER protein FKBP65 cause autosomal-recessive osteogenesis imperfecta. PMID: 20362275
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相關(guān)疾病：Osteogenesis imperfecta 11 (OI11); Bruck syndrome 1 (BRKS1)
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亞細(xì)胞定位：Endoplasmic reticulum lumen.
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數(shù)據(jù)庫(kù)鏈接：
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