FEZF1 Antibody

中文名稱：

FEZF1兔多克隆抗體
貨號：

CSB-PA008602LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: U251 whole cell lysate
All lanes: FEZF1 antibody at 6µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 53, 47, 52 kDa
Observed band size: 53 kDa

IHC image of CSB-PA008602LA01HU diluted at 1:400 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) FEZF1 Polyclonal antibody
Uniprot No.：

A0PJY2
基因名：

FEZF1
別名：

FEZ antibody; FEZ family zinc finger 1 antibody; Fez family zinc finger protein 1 antibody; fez like antibody; fezf1 antibody; FEZF1_HUMAN antibody; Zinc finger protein 312 like antibody; Zinc finger protein 312B antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Fez family zinc finger protein 1 protein (1-115AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，FEZF1 Antibody (CSB-PA008602LA01HU)，的標記方式是Non-conjugated。對于FEZF1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA008602LB01HU	FEZF1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA008602LC01HU	FEZF1 Antibody, FITC conjugated
Biotin	CSB-PA008602LD01HU	FEZF1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:200-1:500

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors.
基因功能參考文獻：
1. FEZF1 was significantly increased in glioma tissues. Over-expressed FIZF1 was associated with reduced survival. PMID: 30030762
2. loss of FEZF1 impairs the pluripotency exit of hESCs during neural specification, which partially explains the neural induction defect caused by FEZF1 deletion. PMID: 29318501
3. FEZF1plays a novel role in regulating the malignant behavior of glioma stem cells as a part of Linc00152/miR-103a-3p/FEZF1/CDC25A axis.FEZF1 up-regulated the promoter activities and bound to the promoters of CDC25A in glioma stem cells. PMID: 28651608
4. High expression of long noncoding RNA FEZF1 was significantly associated with later stage and higher grade of gastric cancer. PMID: 29239821
5. SEZ6L, HISPPD1, FEZF1, SAMD11 gene variants may be associated with autism spectrum disorder. PMID: 26204995
6. Fezf1 and Fezf2 accomplish both independent and redundant functions across diverse tissue and cell types. [Review] PMID: 24913420
7. Mutations in FEZF1 cause Kallmann syndrome. PMID: 25192046
8. the aberrant expression of ZNF312b promotes gastric tumorigenesis through epigenetic modification of its promoter region and provides a molecular mechanism for ZNF312b expression to contribute to the progression of gastric cancer. PMID: 21170990
9. Study is the first to report that ZNF312b, a novel transcription factor, was associated with tumorigenicity of gastric cancer. PMID: 19318583
10. Observational study of gene-disease association. (HuGE Navigator) PMID: 19401682
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相關疾病：

Hypogonadotropic hypogonadism 22 with or without anosmia (HH22)
亞細胞定位：

Nucleus.
蛋白家族：

Krueppel C2H2-type zinc-finger protein family
組織特異性：

Expressed in brain. Little or no expression in other tissues. Overexpressed specifically in gastric cancers. A 2- to 20-fold increase is found in over 50% of gastric cancer tissues.
數據庫鏈接：

HGNC: 22788

OMIM: 613301

KEGG: hsa:389549

STRING: 9606.ENSP00000411145

UniGene: Hs.553970

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