FBXW4 Antibody

說明書

中文名稱：

FBXW4兔多克隆抗體
貨號：

CSB-PA008525ESR2HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA008525ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA008525ESR2HU at dilution of 1:100
其他：

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) FBXW4 Polyclonal antibody
Uniprot No.：

P57775
基因名：

FBXW4
別名：

FBXW4 antibody; FBW4 antibody; SHFM3 antibody; F-box/WD repeat-containing protein 4 antibody; Dactylin antibody; F-box and WD-40 domain-containing protein 4 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human F-box/WD repeat-containing protein 4 protein (143-412AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling.
基因功能參考文獻：
1. biochemical characterization of the novel F-box and WD40 containing protein, FBXW4 PMID: 23658844
2. a complex rearrangement associated with a approximately 0.5 Mb tandem duplication ion containing a disrupted extra copy of the DACTYLIN gene and the entire LBX1 and beta-TRCP genes. PMID: 12913067
3. results indicate that genomic rearrangement of SHFM3 is rare among non-syndromic SHFM patients and emphasize the importance of screening for genomic rearrangements even in sporadic cases of SHFM PMID: 16235095
4. Genomic rearrangements involving the SHFM3 locus at chromosome 10q24 is associated with syndromic and non-syndromic split-hand/foot malformation PMID: 16761290
相關疾病：

Split-hand/foot malformation 3 (SHFM3)
組織特異性：

Expressed in brain, kidney, lung and liver.
數據庫鏈接：

HGNC: 10847

OMIM: 246560

KEGG: hsa:6468

STRING: 9606.ENSP00000373698

UniGene: Hs.500822

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