FBXO2 Antibody

說明書

中文名稱：

FBXO2兔多克隆抗體
貨號：

CSB-PA892326ESR1HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA892326ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human glioma using CSB-PA892326ESR1HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) FBXO2 Polyclonal antibody
Uniprot No.：

Q9UK22
基因名：

FBXO2
別名：

F box gene 1 antibody; F box only protein 2 antibody; F box protein 2 antibody; F box protein only 2 antibody; F-box only protein 2 antibody; FBG 1 antibody; FBG1 antibody; Fbs 1 antibody; Fbs1 antibody; Fbs2 antibody; FBX 2 antibody; FBX2 antibody; FBX2_HUMAN antibody; FBXO 2 antibody; FBXO2 antibody; Neural F box protein NFB42 antibody; Neural F-box protein; 42-KD; rat; homolog of antibody; NFB 42 antibody; NFB42 antibody; OCP1 antibody; organ of Corti protein 1 antibody; Prpl4 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human F-box only protein 2 protein (1-296AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type.
基因功能參考文獻：
1. Fbs1 GYR variant may be employed for substantially unbiased enrichment of N-linked glycopeptides from human serum PMID: 28534482
2. These results suggest that the FBXO2 variant rs9614 C allele may decrease the Parkinson Disease risk in mainland Han Chinese and may be a biomarker for PD. PMID: 28341977
3. summary, our findings suggest that FBXO2-regulated EMT led to carcinogenicity in gastric cancer and may be a novel target in the diagnosis and treatment of gastric cancer. PMID: 29269301
4. Structural analysis of a function-associated loop mutant of the substrate-recognition domain of Fbs1 ubiquitin ligase has been presented. PMID: 27487926
5. This study provides new knowledge of the CFTR biosynthetic pathway. It suggests that SYVN1 and FBXO2 represent two distinct multiprotein complexes that may degrade DeltaF508-CFTR in airway epithelia and identifies a new role for NEDD8 in regulating DeltaF508-CFTR ubiquitination. PMID: 27756846
6. Although the overall structure of FBG3 is similar to that of Fbs1, the residues that form the Fbs1 carbohydrate-binding pocket failed to be superposed with the corresponding residues of FBG3. PMID: 26460611
7. FBG1 degrades A1AT-Z through a Beclin1-dependent arm of autophagy. PMID: 26295339
8. FBG1 is unique among known F-box proteins in that it contains a non-canonical D-Box within F-box domain, required for the growth arrest. PMID: 21135578
9. interaction of the HSV-1 UL9 protein with NFB42 results in its polyubiquitination and subsequent degradation by the 26S proteasome PMID: 12904574
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亞細胞定位：

Cytoplasm. Microsome membrane; Peripheral membrane protein; Cytoplasmic side.
數據庫鏈接：

HGNC: 13581

OMIM: 607112

KEGG: hsa:26232

STRING: 9606.ENSP00000346240

UniGene: Hs.132753

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