FBXL5 Antibody
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中文名稱：FBXL5兔多克隆抗體
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貨號(hào)：CSB-PA892451ESR1HU
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規(guī)格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA892451ESR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA892451ESR1HU at dilution of 1:100
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) FBXL5 Polyclonal antibody
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Uniprot No.：
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基因名：FBXL5
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別名：F box and leucine rich repeat protein 5 antibody; F box protein FBL5 antibody; F box/LRR repeat protein 5 antibody; F-box and leucine-rich repeat protein 5 antibody; F-box protein FBL4/FBL5 antibody; F-box/LRR-repeat protein 5 antibody; FBL4 antibody; FBL5 antibody; FBXL5 antibody; FBXL5_HUMAN antibody; FLR1 antibody; p45SKP2 like protein antibody; p45SKP2-like protein antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human F-box/LRR-repeat protein 5 protein (1-310AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.
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基因功能參考文獻(xiàn)：
- Transcriptomic analysis shows downregulation of FBXL5 expression in HSCs of patients with myelodysplastic syndrome. PMID: 28714470
- regulatory circuit involving FBXL5 and CIA acts through both IRPs to control iron metabolism and promote optimal cell growth PMID: 28768766
- analysis of the redox sensing mechanism by which FBXL5 can serve as an iron metabolism regulator within mammalian cells PMID: 28131773
- FBXL5 regulates cortactin through induction of its ubiquitylation, and FBXL5 similarly regulates Snail1. PMID: 25832584
- FBXL5-mediated degradation of CITED2 leads to the activation of HIF-1alpha. PMID: 25956243
- results thus suggest that HERC2 regulates the basal turnover of FBXL5, and that this ubiquitin-dependent degradation pathway contributes to the control of mammalian iron metabolism PMID: 24778179
- F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis PMID: 23135277
- Data indicate that F-box and leucine-rich repeat protein 5 (FBXL5)-Hr (hemerythrin-like domain) undergoes substantive structural changes when iron becomes limiting, accounting for its switch-like behavior. PMID: 22648410
- Detailed molecular and structural characterization of the ligand-responsive hemerythrin domain provides insights into the mechanisms by which FBXL5 serves as a unique mammalian metabolic sensor. PMID: 22253436
- iron homeostasis is regulated by a proteolytic pathway that couples IRP2 degradation to intracellular iron levels through the stability and activity of FBXL5 PMID: 19762596
- observations suggest a mechanistic link between iron sensing via the FBXL5 hemerythrin domain, IRP2 regulation, and cellular responses to maintain mammalian iron homeostasis PMID: 19762597
- Our findings provide a potential mechanism by which p150(Glued) protein function is regulated by SCFs. PMID: 17532294
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亞細(xì)胞定位：Cytoplasm, perinuclear region.
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數(shù)據(jù)庫鏈接：
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