FBLIM1 Antibody

說明書

中文名稱：

FBLIM1兔多克隆抗體
貨號：

CSB-PA008451GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q8WUP2
基因名：

FBLIM1
別名：

2410043F08Rik antibody; Cal antibody; CSX associated LIM antibody; DKFZp434G171 antibody; FBLI1_HUMAN antibody; FBLIM 1 antibody; Fblim1 antibody; FBLP 1 antibody; FBLP-1 antibody; FBLP1 antibody; Filamin binding LIM protein 1 antibody; Filamin-binding LIM protein 1 antibody; Gt10 antibody; MGC105665 antibody; MIG2 interacting protein; antibody; MIG2-interacting protein antibody; Migfilin antibody; Mitogen inducible 2 interacting protein antibody; Mitogen-inducible 2-interacting protein antibody; OTTHUMP00000003118 antibody; OTTHUMP00000003119 antibody; OTTHUMP00000003120 antibody; OTTMUSP00000011062 antibody; OTTMUSP00000011063 antibody; RP11-169K16.5 antibody; RP23-291H3.1 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human FBLIM1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion.
基因功能參考文獻：
1. data implicate FBLIM1 in the pathogenesis of sterile bone inflammation and our findings suggest CRMO is a disorder of chronic inflammation and imbalanced bone remodeling PMID: 28301468
2. the present study emphasizes for the first time to our knowledge the role of Migfilin in osteoarthritis(OA) and highlights the importance of cell-ECM adhesion proteins in OA pathogenesis. PMID: 23237804
3. Migfilin expression is reduced in breast cancer. PMID: 23645746
4. alpha-parvin, beta-parvin and migfilin were expressed in tumor cells in 53%, 2%, 28% and 53% of effusions and 57%, 20%, 83% and 25% of solid lesions, respectively. PMID: 23099104
5. Migfilin positively modulates the expression and activity of epidermal growth factor receptor, and Migfilin-mediated migration and invasion depend on epidermal growth factor receptor-induced PLC-gamma and STAT3-signaling pathways. PMID: 22843679
6. Migfilin promoted beta-catenin degradation by reinforcing the association between beta-catenin and GSK-3beta. PMID: 22246236
7. Migfilin can activate beta1, beta2 and beta3 integrins and promote integrin mediated responses while migfilin depletion impairs the spreading and migration of endothelial cells PMID: 22043318
8. The association between filamin B and FBLP-1 may play a hitherto unknown role in cytoskeletal function, cell adhesion, and cell motility. PMID: 12496242
9. A review of migfilin's role as a key regulator both at cell adhesion sites and nuclei. It's possible role in the pathogenesis of several human diseases is also discussed. PMID: 15701922
10. Migfilin has a role in interacting with vasodilator-stimulated phosphoprotein (VASP) and regulates VASP localization to cell-matrix adhesions and migration PMID: 16531412
11. Results suggest a role for cytoplasmic migfilin in the progression of leiomyosarcomas (LMS) and identify cytoplasmic migfilin as a potentially important biological marker for human LMS progression. PMID: 17711449
12. Loss-of-function mutations in KIND1 result in marked variability in kindlin-1 immunolabeling in Kindler syndrome skin, which is mirrored by similar changes in kindlin-2 and migfilin immunoreactivity. PMID: 18528435
13. analysis of the migfilin-filamin interaction and competition with integrin beta 7 tails PMID: 18829455
14. Migfilin thus acts as a molecular switch to disconnect filamin from integrin for regulating integrin activation and dynamics of extracellular matrix-actin linkage. PMID: 19074766
15. Migfilin interacts with Src and contributes to cell-matrix adhesion-mediated survival signaling PMID: 19833732
顯示更多

收起更多
亞細胞定位：

Cell junction, focal adhesion. Cytoplasm, cytoskeleton, stress fiber.
組織特異性：

Isoform 1 and isoform 3 are expressed in heart, kidney, lung, pancreas, placenta and platelets. Isoform 2 is expressed in brain, heart, kidney, lung, pancreas, placenta, skeletal muscle and platelets.
數據庫鏈接：

HGNC: 24686

OMIM: 607747

KEGG: hsa:54751

STRING: 9606.ENSP00000416387

UniGene: Hs.530101

Most popular with customers

YWHAG Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
XRCC5 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF

Species Reactivity: Human
XDH Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WT1 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WFDC2 Recombinant Monoclonal Antibody

Applications: ELISA, WB, FC

Species Reactivity: Human
WDR5 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
VIM Recombinant Monoclonal Antibody

Applications: ELISA, IHC, IF

Species Reactivity: Human