FAT4 Antibody, FITC conjugated
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中文名稱：FAT4兔多克隆抗體, FITC偶聯
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貨號：CSB-PA740927LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) FAT4 Polyclonal antibody
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Uniprot No.：
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基因名：FAT4
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別名：Cadherin family member 14 antibody; Cadherin related family member 11 antibody; CDHF14 antibody; CDHR11 antibody; FAT atypical cadherin 4 antibody; FAT J antibody; FAT tumor suppressor homolog 4 antibody; Fat-like cadherin protein FAT-J antibody; FAT4 antibody; FAT4_HUMAN antibody; FATJ antibody; hFat4 antibody; HKLLS2 antibody; Nbla00548 antibody; Protocadherin Fat 4 antibody; Putative protein product of Nbla00548 antibody; VMLDS2 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Protocadherin Fat 4 protein (4658-4862AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation.
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基因功能參考文獻：
- The results provide direct evidence that localized feedbacks on Fat4-Ds1 complexes can give rise to planar cell polarity. PMID: 28826487
- Study shows that when key regulators during mammalian cerebral cortical development are disrupted due to DCHS1-FAT4 mutations, functional cerebral asymmetries are stronger. PMID: 25930014
- Epigenetic inactivation of FAT4 contributes to gastric field cancerization. PMID: 26792292
- In hepatocellular carcinoma patients, both FAT4 expression and FAT4 mutational status significantly correlated with patient prognosis. FAT4 acts as a putative tumor suppressor that is frequently inactivated in human hepatocellular carcinoma. PMID: 26672766
- In conclusion, Fat4 expression is deceased in gastric cancer cells, leading to nuclear translocation of Yap and correlates with poor prognosis. PMID: 26575609
- FAT4 has a tumour suppressor role mediated by the modulation of Wnt/beta-catenin signalling, providing potential novel targets for the treatment of gastric cancer PMID: 26633557
- our results reveal a novel inhibitory mechanism of FAT4 gene expression through actin depolymerization during Src-induced carcinogenesis in human breast cells. PMID: 25679223
- These findings suggest that Fat and Dachsous self-bend due to the loss of Ca(2+)-binding amino acids from specific EC-EC linkers, and can therefore adapt to confined spaces. PMID: 25355906
- study defined eight additional recurrently mutated genes in SMZL; these genes are CREBBP, CBFA2T3, AMOTL1, FAT4, FBXO11, PLA2G4D, TRRAP and USH2A. PMID: 24349473
- Homozygosity mapping and whole-exome sequencing was used in the original Hennekam syndrome family with multiple affected individuals in whom no CCBE1 mutation had been detected, and identified a homozygous mutation in the FAT4 gene. PMID: 24913602
- findings show that mutations in genes encoding the receptor-ligand cadherin pair DCHS1 and FAT4 lead to a recessive syndrome in humans that includes periventricular neuronal heterotopia PMID: 24056717
- The atypical cadherin Fat4 encodes at least part of the stromal cell differentiation signal. PMID: 23974041
- the nonsynonymous variants rs1014867 (Pro4972Ser) and rs1039808 (Ala807Val) of FAT4 may contribute to esophageal cancer susceptibility PMID: 23319386
- Recurrent somatic mutations in FAT4 gene is associated with gastric adenocarcinoma. PMID: 22484628
- Fat4 may be a breast tumor suppressor gene PMID: 19048595
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相關疾病：Van Maldergem syndrome 2 (VMLDS2); Hennekam lymphangiectasia-lymphedema syndrome 2 (HKLLS2)
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亞細胞定位：Membrane; Single-pass type I membrane protein.
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組織特異性：Widely expressed. Expressed in fetal brain, infant brain, brain tumor and colorectal cancer.
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數據庫鏈接：
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