FANCF Antibody

Name: FANCF Antibody
Brand: CUSABIO
SKU: CSB-PA873614LA01HU

說(shuō)明書(shū)

中文名稱(chēng)：

FANCF兔多克隆抗體
貨號(hào)：

CSB-PA873614LA01HU
規(guī)格：

￥440
圖片：
Western Blot
Positive WB detected in: HEK293 whole cell lysate, K562 whole cell lysate
All lanes: FANCF antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 43 kDa
Observed band size: 43 kDa
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱(chēng)：

Rabbit anti-Homo sapiens (Human) FANCF Polyclonal antibody
Uniprot No.：

Q9NPI8
基因名：

FANCF
別名：

A730016A17 antibody; FACF antibody; FAF antibody; FANCF antibody; FANCF_HUMAN antibody; Fanconi anemia complementation group F antibody; Fanconi anemia group F protein antibody; MGC126856 antibody; Protein FACF antibody; RGD1561456 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Fanconi anemia group F protein (295-341AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，F(xiàn)ANCF Antibody (CSB-PA873614LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于FANCF Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱(chēng)	應(yīng)用
HRP	CSB-PA873614LB01HU	FANCF Antibody, HRP conjugated	ELISA
FITC	CSB-PA873614LC01HU	FANCF Antibody, FITC conjugated
Biotin	CSB-PA873614LD01HU	FANCF Antibody, Biotin conjugated	ELISA

克隆類(lèi)型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:200-1:2000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.
基因功能參考文獻(xiàn)：
1. LOH in FA genes appears to be a common feature of head and neck squamous cell carcinomas development seen here in 57% of patients and other mutation types may increase this mutation frequency. We suggest larger patient cohorts would be needed to test the observed association of LOH in FANCF and patient survival comprehensively PMID: 28440438
2. we report three patients who illustrate the clinical variability within the FA-F group. This analysis suggests a more severe phenotype for those with the common c.484_485delCT mutation. PMID: 27714961
3. CpG island methylation of FANCF gene promoter region is strongly associated with the susceptibility and clinicopathologic features of epithelial ovarian cancer. PMID: 26507869
4. careful examination of three electively aborted fetuses in one family and one affected girl in the other indicated an association of the FANCF loss-of-function mutation with a severe phenotype characterized by multiple malformations PMID: 26033879
5. Data suggest that the Fanconi anemia group F protein/BRCA1/2 proteins pathway may be a new target to reverse adriamycin (ADR) resistance in leukemia treatment. PMID: 24996439
6. Silencing of FANCF enhanced the antiproliferative effect of ADM in OVCAR3 cells. PMID: 23440494
7. FANCF methylation is a rare event in Japanese primary invasive breast cancer. PMID: 19813073
8. Data identify the gene encoding Fanconi F (FANCF) as an ICSBP target gene. PMID: 19801548
9. inactivation of the FANC-BRCA pathway is relatively common in solid tumors and may be related to tobacco and alcohol exposure and survival PMID: 14647419
10. Inactivation of genes in the FA-BRCA pathway by epigenetic alterations have been found in a high proportion of cervix cancer patients, suggesting a major role for this pathway in the development of cervical cancer. PMID: 15126331
11. FANCF acts as a flexible adaptor protein that plays a key role in the proper assembly of the FA core complex. PMID: 15262960
12. results showed that FANCF methylation regulates the expression of FANCF at both mRNA and protein levels; methylation-induced inactivation of FANCF plays an important role in the occurrence of ovarian cancers via disrupting the FA-BRCA pathway PMID: 16418574
13. human FANCF protein has specific structural components that function in the assembly of a DNA damage signaling complex PMID: 17082180
14. FANCF methylation was rare in breast tumors PMID: 17932744
15. This study does not support methylation-dependent silencing of FANCF as a mechanism of sensitisation to platinum-based chemotherapy in ovarian cancer. PMID: 18414472
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相關(guān)疾病：

Fanconi anemia complementation group F (FANCF)
亞細(xì)胞定位：

Nucleus.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 3587

OMIM: 603467

KEGG: hsa:2188

STRING: 9606.ENSP00000330875

UniGene: Hs.632151

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