FAM3B Antibody

說明書

中文名稱：

FAM3B兔多克隆抗體
貨號：

CSB-PA015538
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA015538(FAM3B Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA015538(FAM3B Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P58499
基因名：

FAM3B
別名：

2-21 antibody; C21orf11 antibody; C21orf76 antibody; Cytokine like protein 2 21 antibody; Cytokine-like protein 2-21 antibody; Fam3b antibody; FAM3B_HUMAN antibody; Family with sequence similarity 3 member B antibody; ORF9 antibody; Pancreatic-derived factor antibody; PANDER antibody; PRED44 antibody; Protein FAM3B antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Fusion protein of Human FAM3B
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.
基因功能參考文獻：
1. Taken together, by activating pro-survival mechanisms FAM3B overexpression contributes to increased resistance to cell death and tumor growth in nude mice, highlighting a putative role for this cytokine in prostate cancer progression. PMID: 29357840
2. FAM3B overexpression contributes to increased resistance to cell death and tumor growth in nude mice. PMID: 29357840
3. Data suggest that serum PANDER levels are significantly elevated in patients with long-standing type 2 diabetes as compared to patients with recently diagnosed type 2 diabetes and control subjects; serum PANDER levels vary according to degree of insulin resistance. PMID: 28161382
4. Circulating level of pancreatic-derived factor (PANDER) in relation to the accumulation in metabolic syndrome suggested that persons with elevated levels of PANDER were associated with an increased risk of metabolic syndrome. PMID: 27181109
5. in-vitro and in-vivo glucose is a potent stimulator of the PANDER promoter within the liver and this response may be facilitated by ChREBP. PMID: 26123584
6. beta-cell-secreted PANDER regulated the hepatic insulin and lipogenenic signaling and impact overall glycemia. PMID: 24468680
7. It is an important regulator of glucose and lipid metabolism and plays a role in the pathogenesis of nonalcoholic fatty liver disease.(review) PMID: 23855304
8. our studies demonstrated that silencing FAM3B promoted p53 phosphorylation and induced p53 accumulation by decreasing Mdm2 expression, which resulted in apoptotic cell death. PMID: 23246487
9. These results suggest that FAM3B-258 promotes colon cancer cell invasion and metastasis through upregulation of Slug. PMID: 23059759
10. Localized to the islets of Langerhans. PMID: 12160727
11. Helices B and C and the second disulfide bond of PANDER are essential for PANDER-induced beta-cell death. PMID: 16114871
12. PANDER is secreted from 2 types of pancreatic cells, glucose stimulates its secretion in beta cell and primary islets but not in alpha-cells, it is likely cosecreted with insulin, and structure and conformation is vital for PANDER secretion. PMID: 16249448
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亞細胞定位：

Secreted. Note=Present in insulin secretory granules and likely cosecreted with insulin. Localized in discrete vesicular and perinuclear structure.
蛋白家族：

FAM3 family
組織特異性：

Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis.
數據庫鏈接：

HGNC: 1253

OMIM: 608617

KEGG: hsa:54097

STRING: 9606.ENSP00000350673

UniGene: Hs.473877

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