F Antibody

Name: F Antibody
Brand: CUSABIO
SKU: CSB-PA318261LA01CCQ

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說明書

產品詳情

產品描述：

F polyclonal antibody CSB-PA318261LA01CCQ was produced in rabbit immunized by using the Recombinant Canine distemper virus Fusion glycoprotein F0 protein (136-608AA) as the immunogen. The target protein F is class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes.
This Rabbit anti-Canine distemper virus (strain Onderstepoort) (CDV) F Polyclonal antibody was tested in the ELISA. The non-conjugated IgG got purified by protein G and reached up to 95% in purity. It only reacts with the F proteins of canine distemper virus-origin and may be used to detect the endogenous levels of F protein.
產品名稱：

Rabbit anti-Canine distemper virus F Polyclonal antibody
Uniprot No.：

P12569
基因名：

F
別名：

F antibody; Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1] antibody
宿主：

Rabbit
反應種屬：

Canine distemper virus
免疫原：

Recombinant Canine distemper virus Fusion glycoprotein F0 protein (136-608AA)
免疫原種屬：

Canine distemper virus

標記方式：

Non-conjugated

本頁面中的產品，F Antibody (CSB-PA318261LA01CCQ)，的標記方式是Non-conjugated。對于F Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA318261LB01CCQ	F Antibody, HRP conjugated	ELISA
FITC	CSB-PA318261LC01CCQ	F Antibody, FITC conjugated
Biotin	CSB-PA318261LD01CCQ	F Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes. Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. This fusion is pH independent and occurs directly at the outer cell membrane. The trimer of F1-F2 (F protein) probably interacts with H at the virion surface. Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes. Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis.
亞細胞定位：

Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass membrane protein.
蛋白家族：

Paramyxoviruses fusion glycoprotein family

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