EZH1 Antibody
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中文名稱：EZH1兔多克隆抗體
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貨號：CSB-PA002349
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規格：￥1090
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圖片：
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Western Blot analysis of COS7 cells using ENX-2 Polyclonal Antibody -
Western Blot analysis of HT29 LOVO A549 NIH-3T3 cells using ENX-2 Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：Enhancer of zeste homolog 1 (Drosophila) antibody; Enhancer of zeste homolog 1 antibody; ENX-2 antibody; ENX2 antibody; Ezh1 antibody; EZH1_HUMAN antibody; Histone-lysine N-methyltransferase EZH1 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Monkey
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免疫原：Synthesized peptide derived from the Internal region of Human ENX-2.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, IF, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:40000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
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基因功能參考文獻：
- identification of EZH1 as a repressor of haematopoietic multipotency in the early mammalian embryo PMID: 29342143
- pVHL loss causes the transcriptional activation of hypoxia-inducible factor (HIF) target genes, including many genes that encode histone lysine demethylases. PMID: 28701475
- Data show that embryonic stem cells with deletion of EZH1 or EZH2 fail to differentiate into ectoderm lineages. PMID: 28939884
- Expression of the EZH2 homolog EZH1 is reduced in EZH2-deficient CML LICs, creating a scenario resembling complete loss of PRC2. EZH2 dependence of CML LICs raises prospects for improved therapy of TKI-resistant CML and/or eradication of disease by addition of EZH2 inhibitors PMID: 27630126
- a hot-spot mutation in EZH1 is the second most frequent genetic alteration in autonomous thyroid adenomas; the association between EZH1 and TSHR mutations suggests a 2-hit model for the pathogenesis of these tumors, whereby constitutive activation of the cAMP pathway and EZH1 mutations cooperate to induce the hyperproliferation of thyroid cells PMID: 27500488
- EZH1, SUZ12 and UXT work synergistically to regulate pathway activation in the nucleus. PMID: 27127229
- The authors report a novel PRC2-Ezh1 function that utilizes Ezh1beta as an adaptive stress sensor in the cytoplasm, thus allowing postmitotic cells to maintain tissue integrity in response to environmental changes. PMID: 28346433
- These evidences suggest that EZH2 and EZH1 are important in the counter-balancing mechanisms controlling proliferation/resting of lymphoid cells. The disruption of the balanced EZH2/EZH1 ratio may play important roles in the pathogenesis of lymphomas PMID: 27311868
- The related enzymatic subunits EZH1 and EZH2 undergo an expression switch during blood cell development. PMID: 25578878
- EZH1 maintains repressive chromatin through different mechanisms. PMID: 19026781
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亞細胞定位：Nucleus. Note=Colocalizes with trimethylated 'Lys-27' of histone H3.
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蛋白家族：Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, EZ subfamily
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數據庫鏈接：
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