EXOSC5 Antibody, HRP conjugated

說明書

中文名稱：

EXOSC5兔多克隆抗體, HRP偶聯(lián)
貨號：

CSB-PA878857LB01HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) EXOSC5 Polyclonal antibody
Uniprot No.：

Q9NQT4
基因名：

EXOSC5
別名：

Chronic myelogenous leukemia tumor antigen 28 antibody; CML28 antibody; EXOS5_HUMAN antibody; EXOSC 5 antibody; Exosc5 antibody; Exosome complex component rrp46 antibody; exosome complex exonuclease RRP46 antibody; Exosome component 5 antibody; exosome component Rrp46 antibody; hRrp46p antibody; p12B antibody; Ribosomal RNA processing protein 46 antibody; Ribosomal RNA processing protein 46, S. cerevisiae, homolog of antibody; Ribosomal RNA-processing protein 46 antibody; RRP41B antibody; RRP46 antibody; Rrp46p antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Exosome complex component RRP46 protein (1-235AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
基因功能參考文獻(xiàn)：
1. Further, subcellular co-localization assay showed that the two proteins could co-localize in the cytoplasm of K562 cells, but WT1/CML28 complexes were not detected by using immunoprecipitation. PMID: 23392705
2. Results suggest that Rrp46 forms a homodimer separately from exosome complexes and, depending on species, is a structural component of the machinery that cleaves DNA during apoptosis. PMID: 20660080
3. association of hCsl4p with the exosome is mediated by protein-protein interactions with hRrp42p and hRrp46p PMID: 11812149
4. These results in our study indicates gene silencing of SOCS1 remarkably enhanced the cytotoxicity efficiency of CML28 DNA vaccine in DCs. PMID: 16815301
5. rAAV/CML28-transduced DCs vaccine may serve as a feasible approach for the treatment of CML28-associated cancers. PMID: 18157497
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亞細(xì)胞定位：

Nucleus, nucleolus. Cytoplasm. Nucleus.
蛋白家族：

RNase PH family
組織特異性：

Highly expressed in a variety of hematopoietic and epithelial tumor cell lines, but not in normal hematopoietic tissues or other normal tissue, with the exception of testis.
數(shù)據(jù)庫鏈接：

HGNC: 24662

OMIM: 606492

KEGG: hsa:56915

STRING: 9606.ENSP00000221233

UniGene: Hs.283741

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