ETV5 Antibody

中文名稱：

ETV5兔多克隆抗體
貨號：

CSB-PA007859LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: PC-3 whole cell lysate, A549 whole cell lysate
All lanes: ETV5 antibody at 4.6µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 58, 63 kDa
Observed band size: 58 kDa

IHC image of CSB-PA007859LA01HU diluted at 1:600 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA007859LA01HU diluted at 1:600 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ETV5 Polyclonal antibody
Uniprot No.：

P41161
基因名：

ETV5
別名：

ERM antibody; Ets related protein ERM antibody; ETS translocation variant 5 antibody; Ets variant gene 5 antibody; Ets-related protein ERM antibody; ETV5 antibody; ETV5_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human ETS translocation variant 5 protein (124-265AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，ETV5 Antibody (CSB-PA007859LA01HU)，的標記方式是Non-conjugated。對于ETV5 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA007859LB01HU	ETV5 Antibody, HRP conjugated	ELISA
FITC	CSB-PA007859LC01HU	ETV5 Antibody, FITC conjugated
Biotin	CSB-PA007859LD01HU	ETV5 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:500-1:1000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'.
基因功能參考文獻：
1. exploration of the underlying mechanism demonstrated that ICAM3 not only binds to LFA-1 with its extracellular domain and structure protein ERM but also to lamellipodia with its intracellular domain which causes a tension that pulls cells apart (metastasis). PMID: 29729315
2. High Etv5 expression is associated with glioma. PMID: 29787563
3. Novel ETV5 SNP rs7647305 is associated with childhood hypertension adjusted by obesity. PMID: 28645872
4. MiR-200b inhibition by transfection in MCF-7 markedly decreased miR-200b level, elevated ERM expression, and enhanced cell migration and invasion. MiR-200b overexpression in MDA-MB-231 obviously increased miR-200b level, reduced ERM expression, and weakened cell migration and invasion. PMID: 27276064
5. Resistin, a fat-derived secretory factor, promotes metastasis of MDA-MB-231 human breast cancer cells through ERM activation PMID: 26729407
6. ERM proteins contribute toward accelerated CD44 shedding by MT1-MMP through ERM protein-mediated interactions between their cytoplasmic tails. PMID: 26289026
7. Our results reveal a novel ERM-based spatial mechanism that is coopted by DLBCL cells to sustain tumor cell growth and survival. PMID: 25801911
8. Increase of ETV5 protein expression is associated with endometrial cancer invasion. PMID: 25924802
9. Snail regulates the motility and invasiveness of oral cancer cells via RhoA/Cdc42/p-ERM pathway. PMID: 25172658
10. there is a higher expression of ERM/ETV5 in early stages of endometrioid endometrial carcinomas PMID: 24756106
11. we found that the downregulation of ETV5 reduced the expression of the oncogenic transcription factor FOXM1. PMID: 22589409
12. This data suggests that ETV5 has a significant role in regulating MMP2 expression and therefore matrix resorption in human chondrosarcoma, and thus may be a targetable upstream effector of the metastatic cascade in this cancer. PMID: 22968857
13. we propose ETV5-transcriptional regulation of the EMT process through a crosstalk with the tumor surrounding microenvironment, as a principal event initiating EC invasion. PMID: 22266854
14. The homozygous +48845 G>T (TT allele) variant confers a higher risk for male infertility associated with nonobstructive azoospermia and Sertoli cell only syndrome in Australian men. PMID: 22771031
15. Upregulation of ETV5 induced the expression of cell adhesion molecules and enhanced cell survival in a spheroid model. PMID: 21520040
16. results indicate concurrent mechanisms in expression of MMP-2 and -9, RUNX1/AML1 and ETV5/ERM, and several basement membrane components, which likely associate with the invasive stage of endometrioid endometrial and ovarian endometrioid carcinoma. PMID: 20970160
17. The flexible nature of transactivation domain may be instrumental for ERM recognition and binding to diverse molecular partners. PMID: 20647002
18. functional role for the ERMs (ezrin/radixin/moesin) as adaptor molecules in the interactions of adhesion receptors and intracellular tyrosine kinases PMID: 12387735
19. ERM has a role in progression of breast cancer PMID: 15534105
20. The erm gene expression is regulated by the conventional PKC (cPKC) pathway. PMID: 15620692
21. CD44-mediated hyaluronan binding in myeloid cells is regulated by phosphorylated ERM and the actin cytoskeleton. PMID: 15652352
22. ERM is subject to SUMO modification and this post-translational modification causes inhibition of transcription-enhancing activity PMID: 15857832
23. Erm is involved in SP-C regulation, which results from an interaction with TTF-1 PMID: 16613858
24. analysis of NHERF recognition by ERM proteins PMID: 16615918
25. Testing various shorter fragments of ERM as bait indicated that the region essential for binding CHD3/ZFH is within the amino acid region 96-349, which contains the central inhibitory DNA-binding domain (CIDD) of ERM PMID: 17489097
26. ERM/ETV5 up-regulation activates MMP-2 and thus has a role during myometrial infiltration in endometrial cancer PMID: 17638886
27. A TMPRSS2:ETV5 gene fusion was identified in prostate cancer. PMID: 18172298
顯示更多

收起更多
亞細胞定位：

Nucleus.
蛋白家族：

ETS family
組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 3494

OMIM: 601600

KEGG: hsa:2119

STRING: 9606.ENSP00000306894

UniGene: Hs.43697

Most popular with customers

YWHAB Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF, FC

Species Reactivity: Human, Mouse, Rat
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
XRCC5 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF

Species Reactivity: Human
XPNPEP1 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
XDH Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WT1 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WFDC2 Recombinant Monoclonal Antibody

Applications: ELISA, WB, FC

Species Reactivity: Human
WDR5 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human