ERP44 Antibody

說明書

中文名稱：

ERP44兔多克隆抗體
貨號：

CSB-PA998877
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA998877(ERP44 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA998877(ERP44 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A431 and hela cell, Primary antibody: CSB-PA998877(ERP44 Antibody) at dilution 1/450 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
其他：

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靶點詳情

產品詳情

Uniprot No.：

Q9BS26
基因名：

ERP44
別名：

Endoplasmic reticulum resident protein 44 antibody; Endoplasmic reticulum resident protein 44 kDa antibody; Endoplasmic reticulum resident protein ERp44 antibody; ER protein 44 antibody; ERp44 antibody; ERP44_HUMAN antibody; KIAA0573 antibody; PDIA10 antibody; Protein disulfide isomerase family A; member 10 antibody; Thioredoxin domain containing 4 (endoplasmic reticulum) antibody; Thioredoxin domain containing protein 4 antibody; Thioredoxin domain-containing protein 4 antibody; UNQ532/PRO1075 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Fusion protein of Human ERP44
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum.
基因功能參考文獻：
1. Endogenous ERp44 is O-glycosylated and secreted by human primary endometrial cells, suggesting possible pathophysiological roles of these processes. PMID: 25097228
2. findings indicated that overexpression of miR-101 could downregulate ERp44 PMID: 24804790
3. the decrease in 5-HT uptake rates of GDM trophoblast is the consequence of defective insulin signaling, which entraps SERT with ERp44 and impairs its glycosylation. PMID: 25512553
4. The ERp44 assembly control cycle couples secretion fidelity and efficiency downstream of the calnexin/calreticulin and BiP-dependent quality control cycles. PMID: 23685074
5. ERp44 together with Ero1-Lalpha plays an important role in disulfide formation of SERT, which may be a prerequisite step for the assembly of SERT molecules in oligomeric form. PMID: 22451649
6. contains a thioredoxin domain with a CRFS motif and is induced during ER stress PMID: 11847130
7. Ero1alpha and Ero1beta are retained in the endoplasmic reticulum by interactions with PDI and ERp44 PMID: 16677073
8. ERGIC-53 provides a platform that receives micro(2)L(2) subunits from the BiP-dependent checkpoint, assisting polymerization. In this process, ERp44 couples thiol-dependent assembly and quality control. PMID: 17805346
9. ERp44-mediated retention of FGE, indicating that noncovalent interactions between ERp44 and FGE are sufficient to mediate ER retention. PMID: 18178549
10. Study shows that SUMF1 interacts with protein disulfide isomerase (PDI) and ERp44, two thioredoxin family members residing in the early secretory pathway, and with ERGIC-53, a lectin that shuttles between the ER and the Golgi. PMID: 18508857
11. Crystal structure of ERp44 at a resolution of 2.6 A, is presented. PMID: 18552768
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亞細胞定位：

Endoplasmic reticulum lumen.
數據庫鏈接：

HGNC: 18311

OMIM: 609170

KEGG: hsa:23071

STRING: 9606.ENSP00000262455

UniGene: Hs.154023

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