ERF Antibody

說明書

中文名稱：

ERF兔多克隆抗體
貨號：

CSB-PA008136
規(guī)格：

￥1090
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

Uniprot No.：

P50548
基因名：

ERF
別名：

ERF antibody; ERF_HUMAN antibody; ETS domain containing transcription factor ERF antibody; ETS domain-containing transcription factor ERF antibody; Ets2 repressor factor antibody; PE 2 antibody; PE-2 antibody; PE2 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from the C-terminal region of Human ERF.
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:40000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment. May be important for regulating trophoblast stem cell differentiation.
基因功能參考文獻(xiàn)：
1. Systematic genomic sequencing of prostate cancer in African-American men revealed new insights into prostate cancer, including the identification of ERF as a prostate cancer gene; somatic copy-number alteration differences; and uncommon PIK3CA and PTEN alterations. This study highlights the importance of inclusion of underrepresented minorities in cancer sequencing studies. PMID: 28515055
2. Identification of novel prostate cancer drivers, ERF, CREB3L1, and POU2F2, using RegNetDriver, a framework for integration of genetic and epigenetic alterations with tissue-specific regulatory network. PMID: 28750683
3. data provide evidence that the oncogenicity of ERG is mediated, in part, by competition with ERF and they raise the larger question of whether other gain-of-function oncogenic transcription factors might also inactivate endogenous tumour suppressors PMID: 28614298
4. We report the molecular aetiology of Chitayat syndrome and discuss potential mechanisms for this distinctive phenotype associated with the p.Tyr89Cys substitution in ERF. PMID: 27738187
5. ERF-related craniosynostosis should be suspected in patients presenting with multiple suture or sagittal synostosis PMID: 26097063
6. This work identifies ERF as a novel regulator of osteogenic stimulation by RAS-ERK signaling, potentially by competing with activating ETS factors in multifactor transcriptional complexes PMID: 23354439
7. Data demonstrate that induction of EGR1 involves ERK-mediated down-regulation of microRNA-191 and phosphorylation of the ETS2 repressor factor (ERF) repressor, which subsequently leaves the nucleus. PMID: 22198386
8. Ets-2 Repressor Factor (ERF) physically interacts with the cytomegalovirus major immediate-early promoter (MIEP) and represses MIEP activity in undifferentiated non-permissive T2 embryonal carcinoma cells PMID: 12533699
9. a complex interplay between Ets/Id family members and c-Myc that may be an important determinant of the diversity of telomerase activity in leukemia and other cancers PMID: 14611815
10. Chromosome 21 transcription factor Ets2, overexpressed in Down syndrome, is expressed in neurons. Overexpression causes increased apoptosis of neurons from Ets2 transgenic mice and also involves activation of caspase-3. PMID: 14678752
11. Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS. PMID: 17525531
12. Erf provides a direct link between the RAS/ERK signaling and the transcriptional regulation of c-Myc and suggests that RAS/ERK attenuation actively regulates cell fate PMID: 17699159
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相關(guān)疾病：

Craniosynostosis 4 (CRS4); Chitayat syndrome (CHYTS)
亞細(xì)胞定位：

Nucleus.
蛋白家族：

ETS family
組織特異性：

Highest levels in testis, ovary, pancreas, and heart.
數(shù)據(jù)庫鏈接：

HGNC: 3444

OMIM: 600775

KEGG: hsa:2077

STRING: 9606.ENSP00000222329

UniGene: Hs.655969

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