EPN1 Antibody
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中文名稱：EPN1兔多克隆抗體
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貨號：CSB-PA002387
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規格：￥1090
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圖片：
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Western Blot analysis of MOuse-brain cells using Epsin 1 Polyclonal Antibody -
Western Blot analysis of K562 cells using Epsin 1 Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：EH domain binding mitotic phosphoprotein antibody; EH domain-binding mitotic phosphoprotein antibody; EPN 1 antibody; Epn1 antibody; EPN1_HUMAN antibody; EPS 15 interacting protein 1 antibody; EPS-15-interacting protein 1 antibody; Epsin 1 antibody; Epsin-1 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the Internal region of Human Epsin 1.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:40000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations. Regulates receptor-mediated endocytosis.
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基因功能參考文獻：
- Membrane-proximal domains ENTH of epsin domain can form a stable hexameric core in presence of phosphatidylinositol 4,5-bisphosphate (PIP2). PMID: 29362354
- Data indicate that clathrin-mediated endocytosis of proto-oncogene protein erbB-3 (ErbB3) is depending on epsin-1. PMID: 26975582
- intrinsically disordered domains are highly potent drivers of membrane curvature PMID: 26204806
- AP-2 and epsin-1 are both required to promote efficient internalization of activated PAR1 and recognize discrete receptor sorting signals PMID: 21965661
- An epsin 1 helix is inserted into one leaflet of the lipid bilayer, inducing curvature; on lipid monolayers epsin alone is sufficient to facilitate the formation of clathrin-coated invaginations PMID: 12353027
- Together, these data provide evidence that CHIP functions to ubiquitylate the endocytic protein Epsin. PMID: 15694383
- epsin 1 promotes endocytosis of the ubiquitinated EGF receptor PMID: 19054389
- Results show that epsin 1, an endocytic adapter protein, regulates mitotic membrane morphology and spindle integrity in HeLa cells. PMID: 19704019
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亞細胞定位：Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Membrane, clathrin-coated pit.
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蛋白家族：Epsin family
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數據庫鏈接：
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