EMP3 Antibody

中文名稱：

EMP3兔多克隆抗體
貨號：

CSB-PA007650LA01HU
規格：

￥440
圖片：
Immunofluorescent analysis of Hela cells using CSB-PA007650LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Western Blot
All lanes: EMP3 antibody at 3µg/ml + Mouse heart tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 19 kDa
Observed band size: 19, 31 kDa
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品描述：

The EMP3 polyclonal antibody was generated in rabbits using recombinant human EMP3 protein (25-65aa) as the immunogen and purified to a level greater than 95% using protein G affinity chromatography. This liquid-form antibody has been tested and proven reactive with human and mouse samples, making it suitable for use in a variety of experimental contexts.

Additionally, this EMP3 polyclonal antibody has been tested in ELISA and WB and has demonstrated its efficacy in recognizing and binding to EMP3 protein. The EMP3 polyclonal antibody's function includes the ability to detect, evaluate, and quantify EMP3 protein levels in biological samples.
產品名稱：

Rabbit anti-Homo sapiens (Human) EMP3 Polyclonal antibody
Uniprot No.：

P54852
基因名：

EMP3
別名：

EMP3; YMP; Epithelial membrane protein 3; EMP-3; Hematopoietic neural membrane protein 1; HNMP-1; Protein YMP
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Epithelial membrane protein 3 protein (25-65AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，EMP3 Antibody (CSB-PA007650LA01HU)，的標記方式是Non-conjugated。對于EMP3 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA007650LB01HU	EMP3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA007650LC01HU	EMP3 Antibody, FITC conjugated
Biotin	CSB-PA007650LD01HU	EMP3 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Probably involved in cell proliferation and cell-cell interactions.
基因功能參考文獻：
1. This study identified and validated a three-gene (EMP3, GSX2 and EMILIN3) prognostic signature in Lower-Grade Gliomas. PMID: 29794476
2. High EMP3 expression is associated with high grade glioma. PMID: 27527869
3. epithelial membrane protein 3 is a downstream effector of TWIST1/2 in inducing epithelial-to-mesenchymal transition in gastric cancer. Epithelial membrane protein 3 upregulation might be associated with gastric cancer metastasis and is a potential indicator of unfavorable overall survival and progression-free survival in gastric cancer patients PMID: 28718375
4. Independent validation with glioma patients tissue (n = 70) and normal brain tissue (n = 19) found PPIC, EMP3 and CHI3L1 were up-regulated in glioma tissue. Survival value validation showed that the three genes correlated with patient survival by Kaplan-Meir analysis, including grades, age and therapy. PMID: 27801851
5. The study provided a new insight into EMP3, suggesting that EMP3 enhances malignancy of hepatocellular carcinoma cells PMID: 26472188
6. EMP3 functions as an oncogene and is regulated by microRNA-765 in primary breast carcinoma. PMID: 26398721
7. The aim of this study was to investigate the EMP3 promoter hypermethylation status in a series of 229 astrocytic and oligodendroglial tumors and in 16 glioblastoma cell lines. PMID: 24083241
8. Decreased expression of EMP3 by promoter methylation is associated by lung cancer PMID: 23920144
9. LOH 19q determines the complete loss of EMP3 function, as the conserved allele is frequently hypermethylated, and this may represent the molecular basis of the higher risk of relapse in this subgroup of grade II oligodendroglioma patients. PMID: 22992787
10. The promoter methylation and mRNA expressions of EMP3 and PCDH-gamma-A11 are closely related with the malignant development of glioma. PMID: 20388442
11. EMP3 overexpression is associated with oligodendroglial tumors PMID: 17187361
12. Oligodendroglial and astrocytic gliomas show EMP3 hypermethylation and aberrant expression. Primary and secondary glioblastomas have distinct genetic profiles and also differ in their epigenetic aberrations. PMID: 17610521
13. Loss of EMP3 is associated with esophageal squamous cell carcinoma. PMID: 18823699
14. Epithelial membrane protein 3 overexpression in breast carcinomas was significantly related to histological grade III , lymph node metastasis , and strong Her-2 expression. PMID: 19270820
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亞細胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

PMP-22/EMP/MP20 family
數據庫鏈接：

HGNC: 3335

OMIM: 602335

KEGG: hsa:2014

STRING: 9606.ENSP00000270221

UniGene: Hs.9999

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