ELMO2 Antibody

中文名稱：

ELMO2兔多克隆抗體
貨號：

CSB-PA836237LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA836237LA01HU at dilution of 1:100

Immunofluorescent analysis of A549 cells using CSB-PA836237LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Western Blot
Positive WB detected in: Mouse heart tissue
All lanes: ELMO2 antibody at 3.4μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 83, 73 kDa
Observed band size: 83 kDa
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ELMO2 Polyclonal antibody
Uniprot No.：

Q96JJ3
基因名：

ELMO2
別名：

CED 12 antibody; Ced 12 homolog 2 antibody; CED 12 homolog A antibody; CED 12A antibody; CED-12 antibody; ced-12 homolog 2 antibody; CED12 antibody; CED12 homolog A antibody; CED12; C. elegans; homolog of; 2 antibody; CED12A antibody; ELMO 2 antibody; ELMO-2 antibody; ELMO2 antibody; ELMO2_HUMAN antibody; Engulfment and cell motility 2 (ced 12 homolog; C. elegans) antibody; Engulfment and cell motility 2 antibody; Engulfment and cell motility gene 2 antibody; Engulfment and cell motility protein 2 antibody; FLJ11656 antibody; hCED 12A antibody; hCED-12A antibody; hCED12A antibody; KIAA1834 antibody; OTTHUMP00000031762 antibody; PH domain protein CED12A antibody; Protein ced 12 homolog A antibody; Protein ced-12 homolog A antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Engulfment and cell motility protein 2 protein (304-371AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，ELMO2 Antibody (CSB-PA836237LA01HU)，的標記方式是Non-conjugated。對于ELMO2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA836237LB01HU	ELMO2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA836237LC01HU	ELMO2 Antibody, FITC conjugated
Biotin	CSB-PA836237LD01HU	ELMO2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:200-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
基因功能參考文獻：
1. These data suggest a novel link between Tiam1 and RhoG/ILK /ELMO2 pathway as upstream effectors of the Rac1-mediated phagocytic process in trabecular meshwork cells. PMID: 27539661
2. studies demonstrate that Elmo2 is a new regulator of insulin-dependent Glut4 membrane translocation through modulating Rac1 activity and Akt membrane compartmentalization. PMID: 27226625
3. findings highlight the necessity of ELMO2 for maintaining vascular integrity, specifically in intramembranous bones; loss-of-function mutations in ELMO2 cause intraosseous vascular malformation by impeding RAC1 signaling PMID: 27476657
4. Axl has a role in phosphorylating the Elmo scaffold proteins to promote Rac activation and cell invasion PMID: 25332238
5. uncovered a role for ELMO in the recruitment of ACF7 to the membrane to promote microtubule capture and stability PMID: 23184944
6. Through its association with ELMO2, ILK plays key roles in the regulation of Rho GTPases and cross-talk pathways between adhesion and growth factor receptors. PMID: 22568984
顯示更多

收起更多
相關疾病：

Vascular malformation, primary intraosseous (VMOS)
亞細胞定位：

Cytoplasm. Cytoplasm, cytosol. Membrane.
組織特異性：

Widely expressed, with a higher expression in skeletal muscle, kidney and placenta.
數據庫鏈接：

HGNC: 17233

OMIM: 606421

KEGG: hsa:63916

STRING: 9606.ENSP00000290246

UniGene: Hs.210469

Most popular with customers

YWHAG Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
YWHAB Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF, FC

Species Reactivity: Human, Mouse, Rat
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
XRCC5 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF

Species Reactivity: Human
XPNPEP1 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
XDH Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WT1 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WFDC2 Recombinant Monoclonal Antibody

Applications: ELISA, WB, FC

Species Reactivity: Human