ELF5 Antibody
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中文名稱：ELF5兔多克隆抗體
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貨號：CSB-PA891540ESR2HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA891540ESR2HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) ELF5 Polyclonal antibody
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Uniprot No.：
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基因名：ELF5
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別名：E74 like factor 5 (ets domain transcription factor) antibody; E74 like factor 5 antibody; E74-like factor 5 antibody; ELF 5 antibody; ELF5 antibody; ELF5_HUMAN antibody; Epithelium restricted ESE 1 related Ets factor antibody; Epithelium restricted ESE1 related Ets factor antibody; Epithelium specific Ets transcription factor 2 antibody; Epithelium-restricted ESE-1-related Ets factor antibody; Epithelium-specific Ets transcription factor 2 antibody; ESE 2 antibody; ESE-2 antibody; ESE2 antibody; Ets domain TF antibody; Ets domain transcription factor antibody; ETS related transcription factor Elf 5 antibody; ETS related transcription factor Elf5 antibody; ETS-related transcription factor Elf-5 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human ETS-related transcription factor Elf-5 protein (1-170AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation.; Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters.
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基因功能參考文獻：
- Elf5 expression was associated with decreased overall and disease-free survival of triple negative breast cancers patients. PMID: 29396764
- When ELF5 was transfected into the parental MCF7 cells that lack CEACAM1, lumen formation was restored, indicating that ELF5 can replace CEACAM1 in this model system of lumenogenesis. PMID: 28800960
- These results support the contention that ABO expression is dependent upon a downstream positive regulatory element functioning through a tissue-restricted transcription factor, Elf5, in epithelial cells. PMID: 27587399
- Low ELF5 expression is associated with ovarian cancer. PMID: 28184931
- The results of this study suggest that ELF5 is a candidate gene that confers genetic susceptibility for pediatric asthma in the Taiwanese population and SNP rs3910901 may have a minor impact on pediatric asthma in the Taiwanese population. PMID: 25648666
- a novel EWSR1/ETS chimeric gene, was identified in a patient diagnosed with refractory AML, suggesting a potential role of leukemogenesis in rare cases of AML. This fusion gene is very likely to exhibit oncogenic potential by interfering with the p53/p21-dependent pathway. PMID: 27627705
- Alternative promoter use, conferring differential regulatory responses, is the main mechanism governing ELF5 action rather than differential transcriptional activity of the isoforms. PMID: 26738740
- Data (including data from studies in transgenic mice) suggest that expression of ELF5 in luminal breast cancer correlates with increased myeloid cell invasion, inflammation, and lung metastasis. PMID: 26717410
- we identified Elf5 as a novel biomarker of urothelial cancer on several biological levels and established a causative link between Elf5 and epithelial-mesenchymal transition in urothelial cancer. PMID: 25629735
- Elf5 expression is inversely correlated with epithelial-mesenchymal transition in prostate cancer. PMID: 25728398
- ELF5 provides a key transcriptional determinant of breast cancer molecular subtype by suppression of estrogen sensitivity in luminal breast cancer cells. PMID: 23300383
- Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2. PMID: 23086238
- Loss of ELF5 is associated with kidney cancer. PMID: 21787113
- ELF5 is expressed in the human placenta in villous cytotrophoblast cells but not in post-mitotic syncytiotrophoblast and invasive extravillous cytotrophoblast cells. PMID: 20354077
- findings show that Ese-2 upregulates K18 gene expression through specific interactions within ETS binding sites in the regulatory first intron of the gene PMID: 15987600
- Our studies have identified a critical stretch of nucleotides that is important for both basal as well as calcium responsive reporter activity and that binds to a nuclear factor, keratinocyte restricted factor (KRF). PMID: 16229011
- Identification of the ESE-2 consensus site and characterization of the transcriptional activation properties of ESE-2 shed new light on its potential as a regulator of target genes. PMID: 16704374
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亞細胞定位：Nucleus.
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蛋白家族：ETS family
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組織特異性：Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, kidney and prostate. Weakly expressed in placenta and lung. Isoform 1 and isoform 2 are differentially expressed in different tiss
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數據庫鏈接：
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