ELAC2 Antibody

說明書

中文名稱：

ELAC2兔多克隆抗體
貨號：

CSB-PA997561
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA997561(ELAC2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA997561(ELAC2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: LoVo cells, Hela cells, Primary antibody: CSB-PA997561(ELAC2 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9BQ52
基因名：

ELAC2
別名：

COXPD17 antibody; elaC homolog 2 (E. coli) antibody; ElaC homolog protein 2 antibody; elaC ribonuclease Z 2 antibody; elaC, E. coli, homolog of, 2 antibody; ELAC2 antibody; ELC2 antibody; FLJ10530 antibody; FLJ36693 antibody; FLJ42848 antibody; Heredity prostate cancer protein 2 antibody; HPC2 antibody; putative prostate cancer susceptibility protein HPC2/ELAC2 antibody; Ribonuclease Z 2 antibody; Ribonuclease Z, long form antibody; Ribonuclease Z2 antibody; RNase Z 2 antibody; RNase Z2 antibody; RNase ZL antibody; RNZ2_HUMAN antibody; tRNA 3 endonuclease 2 antibody; tRNase Z (long form) antibody; tRNase Z 2 antibody; tRNase Z2 antibody; Zinc phosphodiesterase ELAC protein 2 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Fusion protein of Human ELAC2
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:200-1:1000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly.
基因功能參考文獻：
1. This study describes the cardiac phenotype and outcome of ELAC2 mutation in Infantile Cardiomyopathy PMID: 28441660
2. ELAC2 rs11545302 polymorphism was associated with PSA > 20 and rs4792311 was associated with TNM > 2. PMID: 27318894
3. A homozygous splicing mutation in ELAC2 suggests phenotypic variability including intellectual disability with minimal cardiac involvement PMID: 27769300
4. ELAC2 mutations cause a mitochondrial RNA processing defect associated with hypertrophic cardiomyopathy. PMID: 23849775
5. results indicate that ELAC2 functions as a tRNase Z in human mitochondria and suggest that mt-tRNase Z preferentially cleaves molecules already processed by the proteinaceous mtRNase P PMID: 21593607
6. ELAC2 and PTCD1 affect the 3' end processing of tRNAs. PMID: 21857155
7. analysis of dual nuclear/mitochondrial targeting of the ELAC2 gene product by alternative translation initiation PMID: 21559454
8. Data describe polymorphisms in the HPC/ELAC-2 and alpha 1-antitrypsin genes that correlate with human diseases in an Indian population. PMID: 20119870
9. ELAC2 polymorphisms are associated with prostate cancer. PMID: 20231859
10. Our findings corroborate the involvement of ELAC2, MSR1, and RNASEL in the etiology of prostate cancer even in individuals without a family history. PMID: 20086112
11. variation in the putative prostate cancer susceptibility gene ELAC2 contributes to the elevated risk of prostate cancer in Afro-Caribbean males from Tobago PMID: 12384782
12. Meta-analysis of associations of the Ser217Leu and Ala541Thr variants in ELAC2 (HPC2) and prostate cancer PMID: 12515253
13. Although the Leu217 and Thr541 variants of ELAC2 are less common in Japanese than in Caucasians, both variants confer significantly increased risk of prostate cancer in Japanese. PMID: 12522685
14. ELAC2 interacts with the gamma-tubulin complex and perturbation of ELAC2 might promote tumorigenesis through irregular cell division PMID: 12569551
15. There is no evidence that either ELAC2 polymorphism is associated with prostate cancer or PSA level. PMID: 12783937
16. polymorphism of the ELAC2 gene is associated with prostatic cancer risk in Japanese men PMID: 12949798
17. When considering joint genotypes, white men homozygous for the Leu217 variant on an Ala541/Ala541 background had an increased risk of prostate cancer [odds ratio (OR)=1.84; 95% confidence interval (CI), 1.11-3.06]. PMID: 14504198
18. ELAC2 has a role in prostate cancer PMID: 14625808
19. Thr allele at 541 in HPC2/ELAC2 has strong significance in the predisposition of sporadic Pca in Japan. PMID: 15368467
20. Single nucleotide polymorphisms associated with hereditary prostate cancer. PMID: 16114055
21. candidate prostate cancer susceptibility gene ELAC2 potentiates TGF-beta/Smad-induced transcriptional responses PMID: 16636667
22. The oncogenic role of HPC2 in human primary breast carcinomas is determined by its capacity to inhibit INK4a/ARF proteins(p16INK4a, p14ARF, or h-TERT) or to induce telomerase activity. PMID: 17145810
23. Common SNPs and haplotypes of ELAC2 are associated with risk of aggressive prostate cancer. PMID: 18375959
24. Changes in K(M) observed with some of the substitutions suggest contacts between tRNase Z and substrate tRNA in this region, and changes in tRNA structure provide an additional basis for interpretation of the kinetic effects.[tRNase Z] PMID: 18421255
25. HPC2/ELAC2 and RNASEL may play a role, however minor, in prostate cancer risk among African American men. PMID: 18767027
26. The findings reveal that 3' end processing is a limiting step for defective tRNA maturation and demonstrate that overexpression of ELAC2 can promote defective tRNA 3' processing in vivo. PMID: 19555350
27. The present data suggest the possibility that human cytosolic tRNase ZL modulates gene expression through a subset of microRNAs in the cells. PMID: 19751732
28. Observational study and meta-analysis of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 15824169
29. ELAC2 harbors mutations (including a frameshift and a nonconservative missense change) that segregate with prostate cancer in two Utah pedigrees PMID: 11175785
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相關疾病：

Prostate cancer, hereditary, 2 (HPC2); Combined oxidative phosphorylation deficiency 17 (COXPD17)
亞細胞定位：

Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid. Nucleus. Note=Mainly mitochondrial.
蛋白家族：

RNase Z family
組織特異性：

Widely expressed. Highly expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, testis and ovary. Weakly expressed in brain, lung, spleen, thymus, prostate, small intestine, colon and leukocytes.
數據庫鏈接：

HGNC: 14198

OMIM: 176807

KEGG: hsa:60528

STRING: 9606.ENSP00000337445

UniGene: Hs.434232

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