EIF4ENIF1 Antibody

中文名稱：

EIF4ENIF1兔多克隆抗體
貨號(hào)：

CSB-PA873633LA01HU
規(guī)格：

￥440
圖片：
Western Blot
Positive WB detected in: HEK293 whole cell lysate, A549 whole cell lysate, Mouse brain tissue
All lanes: EIF4ENIF1 antibody at 2.7µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 109, 89 kDa
Observed band size: 130 kDa

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA873633LA01HU at dilution of 1:100

Immunofluorescent analysis of MCF-7 cells using CSB-PA873633LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

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產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) EIF4ENIF1 Polyclonal antibody
Uniprot No.：

Q9NRA8
基因名：

EIF4ENIF1
別名：

2610509L04Rik antibody; 4E T antibody; 4E-T antibody; 4ET antibody; 4ET_HUMAN antibody; A930019J01Rik antibody; AA410001 antibody; AU021239 antibody; Clast 4 antibody; Clast4 antibody; D11Ertd166e antibody; eIF4E transporter antibody; Eif4enif1 antibody; Eukaryotic translation initiation factor 4E nuclear import factor 1 antibody; Eukaryotic translation initiation factor 4E transporter antibody; FLJ21601 antibody; FLJ26551 antibody; OTTMUSP00000000698 antibody; OTTMUSP00000005193 antibody; OTTMUSP00000005194 antibody; OTTMUSP00000036075 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human, Mouse
免疫原：

Recombinant Human Eukaryotic translation initiation factor 4E transporter protein (340-630AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，EIF4ENIF1 Antibody (CSB-PA873633LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于EIF4ENIF1 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA873633LB01HU	EIF4ENIF1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA873633LC01HU	EIF4ENIF1 Antibody, FITC conjugated
Biotin	CSB-PA873633LD01HU	EIF4ENIF1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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靶點(diǎn)詳情

功能：

EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation. Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation. Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis. Promotes miRNA-mediated translational repression. Required for the formation of P-bodies. Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay. Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism.
基因功能參考文獻(xiàn)：
1. we demonstrate that joint deletion of two short conserved motifs that bind UNR and DDX6 relieves repression of 4E-T-bound mRNA, in part reliant on the 4E-T-DDX6-CNOT1 axis. PMID: 27342281
2. our data support a model where 4E-T promotes mRNA turnover by physically linking the 3'-terminal mRNA decay machinery to the 5' cap PMID: 26027925
3. neural precursors are transcriptionally primed to generate neurons, but an eIF4E/4E-T complex sequesters and represses translation of proneurogenic proteins to determine appropriate neurogenesis. PMID: 25456498
4. that while both eIF4E1 and eIF4E2 bind 4E-T via the canonical YX 4Lvarphi sequence, nearby downstream sequences also influence eIF4E:4E-T interactions PMID: 23991149
5. This work has demonstrated the conserved yet unpredicted and surprising translational control of bound mRNAs by 4E-T, which does not involve eIF4E, nor P-body components. PMID: 24335285
6. Data demonstrate that EIF4ENIF1 is associated with dominantly inherited primary ovarian insufficiency. PMID: 23902945
7. The c-Jun N-terminal kinase (JNK) is targeted to processing bodies in response to oxidative stress and promotes the phosphorylation of 4E-T. PMID: 22966201
8. human P bodies contain the cap-binding protein eIF4E and the related factor eIF4E-transporter (eIF4E-T), suggesting novel roles for these proteins in targeting mRNAs for 5' --> 3' degradation PMID: 15840819
9. A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay is described. PMID: 16157702
10. Overexpression of eIF4E-T triggers the movement of eIF4E into the processing bodies. PMID: 18343217
11. Hsp90 probably contributes to the correct localization of eIF4E and 4E-T to stress granules and also to the interaction between eIF4E and eIF4G, both of which may be needed for eIF4E to acquire the physiological functionality PMID: 19850929
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亞細(xì)胞定位：

Cytoplasm, P-body. Cytoplasm. Nucleus. Nucleus, PML body. Nucleus speckle.
組織特異性：

Widely expressed.
數(shù)據(jù)庫鏈接：

HGNC: 16687

OMIM: 607445

KEGG: hsa:56478

STRING: 9606.ENSP00000328103

UniGene: Hs.517559

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