EIF2B1 Antibody
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中文名稱：EIF2B1兔多克隆抗體
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貨號(hào)：CSB-PA007514GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：EIF2B1
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別名：EI2BA_HUMAN antibody; eIF-2B GDP-GTP exchange factor subunit alpha antibody; EIF2B antibody; Eif2b1 antibody; EIF2BA antibody; Eukaryotic translation initiation factor 2B subunit 1 alpha 26kDa antibody; Eukaryotic translation initiation factor 2B subunit alpha antibody; Translation initiation factor eIF-2B subunit alpha antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human EIF2B1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB,IF
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
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基因功能參考文獻(xiàn)：
- Oligodendrocytes with truncated or deletion mutants eIF2B showed less tolerable to endoplasmic reticulum stress PMID: 26112719
- These data emphasize the importance of eIF2Balpha in mediating the eIF2 kinase translation-inhibitory activity and may provide insight into the complex nature of vesiculovirus oncolysis. PMID: 21795329
- mutational analysis of the eIF2B genes of patients with an antenatal- or early-infantile-onset encephalopathy and an early demise PMID: 14566705
- Biochemical analyses indicate that mutations analyzed in eIF2Balpha and -epsilon reduce the steady-state level of the affected subunit, while the most severe mutant tested, eIF2Bbeta(V341D), forms complexes with reduced stability and lower eIF2B activity. PMID: 14993275
- analysis of novel mutations in patients with eIF2B-related disorders PMID: 15776425
- Study reports 9 novel mutations in EIF2B genes in 8 patients, increasing number of known mutations to more than 120. Using homology modeling, analyzed the impact of novel mutations on the 5 subunits of eIF2B protein (alpha, beta, gamma, delta, epsilon) PMID: 18263758
- The authors suspected VWM and sequenced the genes EIF2B1-5, which revealed one heterozygous mutation in EIF2B4. PMID: 18330844
- Crystal structure of the alpha subunit of human translation initiation factor 2B. PMID: 19631657
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相關(guān)疾病：Leukodystrophy with vanishing white matter (VWM)
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蛋白家族：EIF-2B alpha/beta/delta subunits family
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數(shù)據(jù)庫(kù)鏈接：
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