ECEL1 Antibody

中文名稱：

ECEL1兔多克隆抗體
貨號：

CSB-PA007373LA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA007373LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human cervical cancer using CSB-PA007373LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA007373LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Immunofluorescent analysis of Hela cells using CSB-PA007373LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品描述：

ECEL1 polyclonal antibody CSB-PA007373LA01HU was produced in the rabbit immunized by using the Recombinant Human Endothelin-converting enzyme-like 1 protein (425-775AA) as the immunogen. The target protein ECEL1 is a member of the M13 family of endopeptidases. Members of this family are zinc-containing type II integral-membrane proteins that are important regulators of neuropeptide and peptide hormone activity. Diseases associated with ECEL1 include Arthrogryposis, Distal, Type 5D and Distal Arthrogryposis.
This Rabbit anti-Homo sapiens (Human) ECEL1 Polyclonal antibody was tested in the IF, IHC and ELISA applications. The non-conjugated IgG got purified by protein G and reached up to 95% in purity. It only reacts with the ECEL1 proteins of human-origin and may be used to detect the endogenous levels of ECEL1 protein.
產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) ECEL1 Polyclonal antibody
Uniprot No.：

O95672
基因名：

ECEL1
別名：

ECEL1; XCE; UNQ2431/PRO4991; Endothelin-converting enzyme-like 1; Xce protein
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Endothelin-converting enzyme-like 1 protein (425-775AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，ECEL1 Antibody (CSB-PA007373LA01HU)，的標(biāo)記方式是Non-conjugated。對于ECEL1 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA007373LB01HU	ECEL1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA007373LC01HU	ECEL1 Antibody, FITC conjugated
Biotin	CSB-PA007373LD01HU	ECEL1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides.
基因功能參考文獻(xiàn)：
1. Mutation of a conserved residue in ECEL1 is linked with fetal arthrogryposis multiplex congenita. PMID: 25708584
2. Our clinical findings are consistent with recessive ECEL1 mutations causing variably penetrant orbital dysinnervation phenotypes (ptosis and/or complex strabismus with abnormal synkinesis) PMID: 25173900
3. Three novel ECEL1 mutations have been identified in consanguineous pedigrees of Saudi Arabian origin presenting with distal arthrogryposis type 5D. PMID: 23829171
4. A novel missense c.1819G>A mutation (G607S) in the ECEL1 gene has been identified in a consanguineous pedigree of Turkish origin presenting with congenital contracture syndromes. PMID: 23808592
5. We described a new and homogenous phenotype of DA associated with ECEL1 that resulted in symptoms involving rather the peripheral than the central nervous system and suggesting a developmental dysfunction PMID: 23236030
6. Mutations in ECEL1 cause distal arthrogryposis type 5D. PMID: 23261301
7. Sp1 recruits ATF3, c-Jun, and STAT3 to obtain the requisite synergistic effect in neuronal injury through DINE neuronal injury-inducible gene PMID: 18192274
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相關(guān)疾?。?/div>
Arthrogryposis, distal, 5D (DA5D)
亞細(xì)胞定位：

Membrane; Single-pass type II membrane protein.
蛋白家族：

Peptidase M13 family
組織特異性：

Highly expressed in the CNS, in particular in putamen, spinal cord, medulla and subthalamic nucleus. A strong signal was also detected in uterine subepithelial cells and around renal blood vessels. Detected at lower levels in amygdala, caudate, thalamus,
數(shù)據(jù)庫鏈接：

HGNC: 3147

OMIM: 605896

KEGG: hsa:9427

STRING: 9606.ENSP00000302051

UniGene: Hs.26880

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