EBF3 Antibody

中文名稱：

EBF3兔多克隆抗體
貨號：

CSB-PA880977LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Colo320 whole cell lysate, A549 whole cell lysate
All lanes: EBF3 antibody at 5.6μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 65, 61 kDa
Observed band size: 65 kDa
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) EBF3 Polyclonal antibody
Uniprot No.：

Q9H4W6
基因名：

EBF3
別名：

COE 3 antibody; COE3 antibody; COE3_HUMAN antibody; Early B cell factor 3 antibody; Early B-cell factor 3 antibody; EBF 3 antibody; EBF-3 antibody; EBF3 antibody; O/E 2 antibody; O/E-2 antibody; O/E2 antibody; OE 2 antibody; OE-2 antibody; OE2 antibody; Olf 1/EBF like 2 antibody; Olf-1/EBF-like 2 antibody; Transcription factor COE3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Transcription factor COE3 protein (416-530AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，EBF3 Antibody (CSB-PA880977LA01HU)，的標記方式是Non-conjugated。對于EBF3 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA880977LB01HU	EBF3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA880977LC01HU	EBF3 Antibody, FITC conjugated
Biotin	CSB-PA880977LD01HU	EBF3 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcriptional activator. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.
基因功能參考文獻：
1. Data show that early B-cell factor 3 (EBF3) was identified as the direct downstream target gene of miR-23b-3p. PMID: 29750239
2. Associations of Pulmonary Fibrosis with Peripheral Blood Th1/Th2 Cell Imbalance and EBF3 Gene Methylation in Uygur Pigeon Breeder's Lung Patients. PMID: 29913442
3. Results found that hypermethylation of the EBF3 promoter was associated with increased EBF3 mRNA levels in metastatic melanomas and subsequent inhibition of DNA methylation reduced EBF3 expression, suggesting that EBF3 promoter hypermethylation may be a candidate epigenetic driver of metastasis. PMID: 28030832
4. In 11 affected individuals from 11 unrelated families, we identified de novo variants in EBF3 as potentially causative for the neurodevelopmental phenotype. The variants include one nonsense, two frameshift deletions, one splice, and three missense variants. There are three de novo missense variants, (p.(Lys64Thr), p.(His157Gln), and p.(Arg209Gln), which are all in the COE1 DNA-binding domain. PMID: 29162653
5. EBF3, a transcription factor previously unknown to be associated with human disease, is important for brain and other organ development and warrants further investigation PMID: 28017370
6. findings indicate that mutations in EBF3 cause a genetic neurodevelopmental syndrome and suggest that loss of EBF3 function might mediate a subset of neurologic phenotypes shared by ARX-related disorders, including intellectual disability, abnormal genitalia, and structural CNS malformations PMID: 28017372
7. findings demonstrate that variants disrupting EBF3-mediated transcriptional regulation cause intellectual disability and developmental delay and are present in approximately 0.1% of individuals with unexplained neurodevelopmental disorders PMID: 28017373
8. Early B-cell factor 3 (EBF3) is a novel tumor suppressor gene with promoter hypermethylation in pediatric acute myeloid leukemia PMID: 25609158
9. EBF3 tumor suppressor is epigenetically silenced and that it serves as an independent prognostic marker in gastric carcinoma. PMID: 21387304
10. Results verify IRX1, EBF3, SLC5A8, SEPT9, and FUSSEL18 as valid methylation markers in two separate sets of HNSCC specimens; also preliminarily show a trend between HPV16 positivity and target gene hypermethylation of IRX1, EBF3, SLC5A8, and SEPT9. PMID: 20029986
11. Findings suggested that the transfection of EBF3 gene into HepG2 induced the cell proliferation from G1 phase to G2 phase by increasing the number of cells. PMID: 18845077
12. Expression of EBF3 resulted in cell cycle arrest and apoptosis. EBF3 regulates a transcriptional program underlying a putative tumor suppression pathway. PMID: 17018599
13. Frequent methylation of EBF3 gene is associated with head and neck squamous cell carcinoma PMID: 18559491
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相關疾病：

Hypotonia, ataxia, and delayed development syndrome (HADDS)
亞細胞定位：

Nucleus.
蛋白家族：

COE family
組織特異性：

Expressed in brain.
數據庫鏈接：

HGNC: 19087

OMIM: 607407

KEGG: hsa:253738

UniGene: Hs.591374

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