Dsg3 Antibody, HRP conjugated

說明書

中文名稱：

Dsg3兔多克隆抗體, HRP偶聯
貨號：

CSB-PA007205LB01MO
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Mus musculus (Mouse) Dsg3 Polyclonal antibody
Uniprot No.：

O35902
基因名：

Dsg3
別名：

Dsg3Desmoglein-3 antibody; 130 kDa pemphigus vulgaris antigen homolog antibody
宿主：

Rabbit
反應種屬：

Mouse
免疫原：

Recombinant Mouse Desmoglein-3 protein (50-617AA)
免疫原種屬：

Mus musculus (Mouse)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
基因功能參考文獻：
1. flotillin has a role in desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes PMID: 27346727
2. Desmoglein 3 deficiency in mice leads to a phenotype characterized by cyclic alopecia in addition to the dramatic skin and mucocutaneous acantholysis observed in pemphigus patients. PMID: 25542773
3. Dsg3, via p38 MAPK, regulates the spatial distribution of the keratin filament network and stabilizes cell adhesion. PMID: 24782306
4. Squamous metaplasia after pulmonary epithelial injury may play a crucial role in redirecting the skin-specific autoimmune reaction to the lungs in paraneoplastic pemphigus (PNP). PMID: 23729442
5. Dsg3 deficiency results in perturbation of the desmosomal network at the transcriptional, translational, and interaction level, kinase activation, proteinase-mediated degradation, and hyper-adhesion. (Review) PMID: 23368972
6. Thus, Dsg3 does not display a clear function as a tumor suppressor in these mouse skin cancer models PMID: 23185521
7. IgG and IgM antibodies against desmoglein 3 have a pathogenic role in blister formation in pemphigus vulgaris PMID: 21718682
8. the adult passive transfer mouse model is ideally suited for detailed studies of Dsg3 antibody-mediated signaling in adult skin. PMID: 21956125
9. These data indicate a contribution of Dsg depletion to pemphigus vulgaris pathogenesis dependent on Ca(2+)-induced differentiation. PMID: 21864491
10. Aire has an important role in Dsg3 expression as well as in selection of T cells that help B cells to produce anti-Dsg3 IgG in thymus. PMID: 21048786
11. Loss of tolerance against Dsg3 in both B and T cells is important for the development of autoimmune state of pemphigus vulgaris. PMID: 11857336
12. Patchy hair loss in pemphigus vulgaris model mice as in Dsg3(-/-) mice. Ultrastructure of telogen hair follicles same as PV model mice and Dsg3(-/-) mice. Anti-Dsg3 autoantibodies interfere with cell-cell adhesion of keratinocytes in PV model mice. PMID: 12373337
13. perturbation of desmoglein 3 found in the Dsg3bal-Pas mice resulted in disadhesion of keratinocytes manifested with blistering phenotype. PMID: 12485423
14. anti-Dsg3 IgG antibodies can directly access Dsg3 present in desmosomes in vivo and cause the subsequent desmosome separation that leads to blister formation in pemphigus vulgaris PMID: 15140217
15. In pemphigus vulgaris antibodies were dominantly raised against middle to C-terminal extracellular domains of mouse Dsg3 where amino acid sequences are less conserved among desmoglein isoforms. Those antibodies may also be involved in blister formation. PMID: 15265525
16. importance of the companion layer, and particularly the Dsg1 and Dsg3 in this layer, in anchoring the anagen hair to the follicle. PMID: 15482466
17. Northern Blot analysis of wild-type and Plucked (pk) mutant mice indicates that expression of both desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3) is up-regulated in the skin of mutant pk mice PMID: 15629430
18. skin-specific Dsg3 serves as an autoantigen in chronic skin inflammatory diseases accompanied by mast cell degranulation, including both murine systemic lupus erythematosus and other autoinflammatory diseases PMID: 16492738
19. Reduction of Dsg3 might be relevant to blister formation in pemphigus vulgaris. PMID: 17431647
20. distinct T cell responses could be switched after active immunization combined with different adjuvants, resulting in distinct anti-Dsg3 antibody isotypes with different pathogenic activities in Pemphigus disease development PMID: 18634826
21. Subcellular localization of desmosomal components is different between desmoglein3 knockout mice and pemphigus vulgaris model mice. PMID: 19525093
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亞細胞定位：

Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
組織特異性：

Expressed in epidermis.
數據庫鏈接：

KEGG: mmu:13512

STRING: 10090.ENSMUSP00000064718

UniGene: Mm.106811

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