Dll Antibody

^{Rare Species}

說明書

中文名稱：

Dll兔多克隆抗體
貨號：

CSB-PA322586XA01DLU
規格：

￥880
圖片：
Western Blot
Positive WB detected in: recombinant protein
All lanes:Dll Antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 17.8 kDa
Observed band size: 18 kDa
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Drosophila melanogaster (Fruit fly) Dll Antibody Polyclonal antibody
Uniprot No.：

P20009
基因名：

Dll Antibody
別名：

Homeotic protein distal-less (Protein brista) Dll Ba BR CG3629
宿主：

Rabbit
反應種屬：

Drosophila melanogaster (Fruit fly)
免疫原：

Recombinant Drosophila melanogaster (Fruit fly) Dll protein (30-170aa)
免疫原種屬：

Drosophila melanogaster (Fruit fly)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcription factor that plays a role in larval and adult appendage development. Specifies the identity of ventral appendages (including legs and antennae) and suppresses dorsal appendage development. Involved in patterning the distal-proximal limb axis. May control the adhesive properties of cells during limb morphogenesis. Also has a secondary role in the normal patterning of the wing margin.
基因功能參考文獻：
1. Characterization of Dll expression in the developing nervous system supports a role of Dll in neural development and function PMID: 26472170
2. Distal-less regulatory element that controls gene expression in leg precursor cells recruits multiple Hox, Extradenticle (Exd) and Homothorax (Hth) complexes to mediate dual outputs: thoracic activation and abdominal repression. PMID: 27058369
3. Joint ectopic expression of Dll and Rn is sufficient to cell-autonomously activate endogenous bab2 and LAE-driven reporter expression in wing and haltere cells PMID: 23825964
4. findings show a spot of dark pigment on fly wings emerged from assembly of a novel gene regulatory module in which a set of pigmentation genes evolved to respond to a common transcriptional regulator determining their spatial distribution; the primitive wing spot pattern subsequently diversified through changes in expression pattern of this regulator PMID: 23520110
5. Hox proteins regulate Dll transcription in part by locally modifying chromatin structure at the Dll locus. PMID: 22523743
6. studied a 17kb genomic region in the Dll locus which lies downstream of the coding sequence and found control elements of primary functional importance for the expression of Dll in the leg and in other tissues PMID: 21320482
7. The medial leg fates are established via a regulatory cascade in which Wg+Dpp activate Distalless and then Distalless directly activates dac, with Wg+Dpp as less critical, permissive inputs. PMID: 21497759
8. disco plays a fundamental role in the Dll-dependent patterning of antenna and leg, perhaps as a regulator of Dll gene expression PMID: 19756755
9. Distal-less...specify antenna fates via regulation of multiple genes. PMID: 11934862
10. Hox protein Ultrabithorax (Ubx) suppresses limb formation in the abdomen by repressing the leg selector gene Distalless PMID: 12408801
11. Dll functions in subdividing the thoracic limb primordium. PMID: 15712199
12. These findings provide a complete and high-resolution fate map of the Drosophila appendage primordia, linking the primary domains to specific cis-regulatory elements in Dll. PMID: 19036798
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亞細胞定位：

Nucleus.
組織特異性：

Expressed in the embryo in limb primordia of the head and thoracic segments. Expressed in regions of the larval leg, wing, antennal and haltere disks that form the distal-most regions of the mature structures (in the leg this corresponds to the tarsus and
數據庫鏈接：

KEGG: dme:Dmel_CG3629

UniGene: Dm.7063

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