DYRK3 Antibody

中文名稱：

DYRK3兔多克隆抗體
貨號：

CSB-PA007312LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA007312LA01HU diluted at 1:100 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) DYRK3 Polyclonal antibody
Uniprot No.：

O43781
基因名：

DYRK3
別名：

Dual specificity tyrosine (Y) phosphorylation regulated kinase 3 antibody; Dual specificity tyrosine phosphorylation-regulated kinase 3 antibody; Dual specificity tyrosine-phosphorylation-regulated kinase 3 antibody; Dyrk3 antibody; DYRK3_HUMAN antibody; DYRK5 antibody; hYAK3 2 antibody; Protein kinase Dyrk3 antibody; RED antibody; REDK antibody; Regulatory erythroid kinase antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Dual specificity tyrosine-phosphorylation-regulated kinase 3 protein (1-300AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，DYRK3 Antibody (CSB-PA007312LA01HU)，的標記方式是Non-conjugated。對于DYRK3 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA007312LB01HU	DYRK3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA007312LC01HU	DYRK3 Antibody, FITC conjugated
Biotin	CSB-PA007312LD01HU	DYRK3 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material. Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues. Acts as a central dissolvase of membraneless organelles during the G2-to-M transition, after the nuclear-envelope breakdown: acts by mediating phosphorylation of multiple serine and threonine residues in unstructured domains of proteins, such as SRRM1 and PCM1. Does not mediate disassembly of all membraneless organelles: disassembly of P-body and nucleolus is not regulated by DYRK3. Dissolution of membraneless organelles at the onset of mitosis is also required to release mitotic regulators, such as ZNF207, from liquid-unmixed organelles where they are sequestered and keep them dissolved during mitosis. Regulates mTORC1 by mediating the dissolution of stress granules: during stressful conditions, DYRK3 partitions from the cytosol to the stress granule, together with mTORC1 components, which prevents mTORC1 signaling. When stress signals are gone, the kinase activity of DYRK3 is required for the dissolution of stress granule and mTORC1 relocation to the cytosol: acts by mediating the phosphorylation of the mTORC1 inhibitor AKT1S1, allowing full reactivation of mTORC1 signaling. Also acts as a negative regulator of EPO-dependent erythropoiesis: may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1: this in turn inhibits p53/TP53 activity and apoptosis.
基因功能參考文獻：
1. Study identified the dual specificity tyrosine-phosphorylation-regulated kinase 3 (DYRK3) as a protein with the ability to condense P-granule-like speckles in the cytosol and to prevent stress granule dissolution via its N-terminal domain when it is in a kinase-inactive form. PMID: 23415227
2. the lipid raft-dependent endocytosis process mediates C. neoformans internalization into HBMEC and the CD44 protein of the hosts, cytoskeleton, and intracellular kinase-DYRK3 are involved in this process PMID: 21693704
3. DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. PMID: 20167603
4. DYRK3 has roles in kinase activation, binding to CREB, and hematopoietic progenitor cell survival PMID: 12356771
5. DYRK3, expression is strong in erythroid cells and testis, but is also detected in adult kidney and liver PMID: 15607427
6. DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia PMID: 18854306
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亞細胞定位：

Nucleus. Cytoplasm. Nucleus speckle. Cytoplasmic granule. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
蛋白家族：

Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MNB/DYRK subfamily
組織特異性：

Isoform 1: Highly expressed in testis and in hematopoietic tissue such as fetal liver, and bone marrow. Isoform 1: Predominant form in fetal liver and bone marrow. Isoform 1: Present at low levels in heart, pancreas, lymph node and thymus. Isoform 2: High
數據庫鏈接：

HGNC: 3094

OMIM: 603497

KEGG: hsa:8444

STRING: 9606.ENSP00000356076

UniGene: Hs.164267

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