DVL3 Antibody

說明書

中文名稱：

DVL3兔多克隆抗體
貨號：

CSB-PA007287GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q92997
基因名：

DVL3
別名：

Dishevelled 3 (homologous to Drosophila dsh) antibody; Dishevelled 3 antibody; Dishevelled 3; dsh homolog (Drosophila) antibody; Dishevelled; dsh homolog 3 (Drosophila) antibody; Dishevelled-3 antibody; DSH homolog 3 antibody; dvl3 antibody; DVL3_HUMAN antibody; KIAA0208 antibody; OTTHUMP00000210777 antibody; OTTHUMP00000210778 antibody; Segment polarity protein dishevelled homolog DVL 3 antibody; Segment polarity protein dishevelled homolog DVL-3 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human DVL3
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IF
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in the signal transduction pathway mediated by multiple Wnt genes.
基因功能參考文獻：
1. Dvl3 is overexpressed in human HCCs. The NP-Dvl3 is the more stable and active form of the protein and enhances HCC stemness. PMID: 28455968
2. Studied and identified candidate biomarkers of biochemical recurrence (BCR) of prostate adenocarcinoma by integrating reverse-phase protein array (RPPA) and mRNA datafrom The Cancer Genome Atlas (TCGA). Found DVL3 was expressed in patients with a higher risk of BCR. DVL3 may be a novel and easily applicable recurrence predictor of localised prostate adenocarcinoma. PMID: 28107606
3. Genetic changes between MLH1 and MSH2 were significantly positively correlated (p = 0.032). We also noted a positive correlation between genetic changes of MSH2 and DVL3 genes (p = 0.034). PMID: 28705114
4. Kif26b, together with Dvl3/Daam1, initiates cell polarity through the control of planar cell polarity-signaling pathway-dependent activation in endothelial cells. PMID: 26792835
5. DVL3 transcripts decreased in individuals with major depressive disorder PMID: 26008736
6. we demonstrate that normally ALFY attenuates the canonical Wnt signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 and not of Dvl1 or Dvl2. PMID: 27008544
7. All variants in DVL3 result in a -1 frameshift, indicating that these highly specific alterations might be a common cause of dominant Robinow syndrome. PMID: 26924530
8. data suggest that miR-204-5p regulates adipogenesis by controlling DVL3 expression and subsequently inhibiting the activation of the Wnt/beta-catenin signaling pathway. PMID: 25847080
9. Tumors that responded to IGFIR inhibition contain relatively lower levels of DVL3 protein than resistant tumors. PMID: 25168481
10. data (i) support previous the assumption that CK1 acts via phosphorylation of distinct residues as the activator as well as the shut-off signal of Wnt/beta-catenin signaling and (ii) suggest that CK1 acts on Dvl via different mechanism than Fzd5. PMID: 24993822
11. AMPK activators suppress cervical cancer cell growth by impairing DVL3 protein synthesis via AMPK/mTOR signaling and/or partially promoting the proteasomal degradation of DVL3 PMID: 23301094
12. A harmful p.Ser175Gly substitution & 3 benign variants (p.Ile353Val, p.Ile384Val, & p.Ala641Thr) were found in a cohort of patients with neural tube defects but not in controls. PMID: 22892949
13. Dvl3 protein transduce signals via the Wnt proteins non canonical pathways, namely via NFAT protein and Src kinase and novel NPM-ALK interacting proteins and possibly NPM-ALK substrates. PMID: 23022960
14. Letter: report expression of dishevelled-3 and EAAT1 and glutamine metabolism in malignant pleural mesothelioma. PMID: 22569537
15. Identification of novel post translational modifications of DVL3 by liquid chromatography coupled LTQ-Orbitrap analysis. PMID: 22612246
16. In HEK293T cells with intact Wnt signaling, Rac1b is tethered to these same gene promoters independent of Wnt3A stimulation and is further observed to recruit Dishevelled and beta-catenin in the absence of Wnt3A stimulation. PMID: 21667018
17. The facilitation of Prickle-1 on Dvl3 degradation and the suppression of beta-catenin activity and cell growth suggest that Prickle-1 is a negative regulator of the Wnt/beta-catenin signaling pathway PMID: 17030191
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相關疾病：

Robinow syndrome, autosomal dominant 3 (DRS3)
亞細胞定位：

Cytoplasm.
蛋白家族：

DSH family
數據庫鏈接：

HGNC: 3087

OMIM: 601368

KEGG: hsa:1857

STRING: 9606.ENSP00000316054

UniGene: Hs.388116

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