DUSP5 Antibody, Biotin conjugated

說明書

中文名稱：

DUSP5兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA620976LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) DUSP5 Polyclonal antibody
Uniprot No.：

Q16690
基因名：

DUSP5
別名：

Dual specificity phosphatase 5 antibody; Dual specificity protein phosphatase 5 antibody; Dual specificity protein phosphatase hVH 3 antibody; Dual specificity protein phosphatase hVH3 antibody; DUS5_HUMAN antibody; DUSP 5 antibody; DUSP antibody; DUSP5 antibody; HVH 3 antibody; HVH3 antibody; Serine/threonine specific protein phosphatase antibody; VH 3 antibody; VH1 like phosphatase 3 antibody; VH3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Dual specificity protein phosphatase 5 protein (56-181AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1.
基因功能參考文獻：
1. Methylation the DUSP5 gene promoter can serve as an additional means of identifying CIMP-high colorectal cancers. PMID: 29379130
2. DUSP5 expression in skeletal muscle was ninefold higher immediately after exercise and returned to pre-exercise level within 2 h. PMID: 28989118
3. Findings indicate that zinc-finger protein X-linked (ZFX) promotes colorectal cancer (CRC) progression by suppressing dual specificity phosphatase 5 (DUSP5) expression and suggest that ZFX is a prognostic biomarker and potentially useful therapeutic target in stage II/III CRC patients. PMID: 26967242
4. Results show that DUSP5 and DUSP6 mRNA are overexpressed in human PTCs, especially in BRAFV600E mutated papillary thyroid carcinomas (PTCs), and positively control cell migration and invasion. PMID: 28910386
5. role of the secondary binding site in assembling the DUSP5-pERK pre-reactive complex was further demonstrated by molecular dynamics simulations that showed that the remote C197-C219 disulfide linkage controls the structure of the secondary binding pocket based on its redox state (i.e., disulfide/dithiol) and, in turn, the enzymatic activity of DUSP5 PMID: 27739308
6. The DUSP5 S147P protein is hypoactive compared to the DUSP5 wild-type protein. PMID: 25519881
7. Data indicate that cells from Burkitt's lymphoma, leukemia, neuroblastoma and Ewing sarcoma showed a higher dual-specificity phosphatase 5 pseudogene 1 (DUSP5P1)/dual specificity phosphatase 5 (DUSP5 ratio than normal cells. PMID: 24651368
8. DUSP5 methylation may serve as a prognostic marker for gastric cancer (GC), but this requires validation in a larger set of GC samples. PMID: 23402999
9. Studies indicate that dual-specificity MAP kinase phosphatases (MKPs) DUSP6/MKP-3 and DUSP5 are localized in the cytoplasm and nuclear compartments. PMID: 22812510
10. DUSP5 and DUSP6 selectively control ERK pathway activity and proliferation. PMID: 20806045
11. the differential up-regulation of MKP3 by Ets2 and of DUSP5 by c-Jun may converge in similar functional roles for these MAP kinase phosphatases in the growth arrest versus proliferation decisions of breast cancer cells PMID: 20554528
12. In FD-Fms cells, overexpression of human DUSP5 increased M-CSF-dependent proliferation & decreased differentiation. Overexpression in multipotent EGER-Fms cells increased M-CSF-induced proliferation & caused granulocytic, not macrophage, differentiation. PMID: 19801501
13. DUSP5 is a direct target of p53. PMID: 12944906
14. DUSP5 inactivates ERK2 and causes both nuclear translocation and sequestration of inactive ERK2. PMID: 15713638
15. the crystal structure of the catalytic domain of DUSP5 in an active conformation. PMID: 17078075
16. proper regulation of DUSP5 activity is critical for normal immune system development, IL-2 actions, and tolerance PMID: 18430737
17. mutations in dusp-5 and snrk-1 have been identified in affected tissues of patients with vascular anomalies, implicating the Snrk-1-Dusp-5 signaling pathway in human disease. PMID: 18927432
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亞細胞定位：

Nucleus.
蛋白家族：

Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
數據庫鏈接：

HGNC: 3071

OMIM: 603069

KEGG: hsa:1847

STRING: 9606.ENSP00000358596

UniGene: Hs.2128

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