DUSP12 Antibody

說明書

中文名稱：

DUSP12兔多克隆抗體
貨號：

CSB-PA229389
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA229389(DUSP12 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Jurkat cells, Primary antibody: CSB-PA229389(DUSP12 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
其他：

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靶點詳情

產品詳情

Uniprot No.：

Q9UNI6
基因名：

DUSP12
別名：

Dual specificity phosphatase 12 antibody; Dual specificity protein phosphatase 12 antibody; Dual specificity tyrosine phosphatase YVH1 antibody; DUS12_HUMAN antibody; DUSP 1 antibody; DUSP 12 antibody; DUSP1 antibody; DUSP12 antibody; Serine/threonine specific protein phosphatase antibody; TDSP4 antibody; YVH 1 antibody; YVH1 antibody; YVH1 protein tyrosine phosphatase (S. cerevisiae) ortholog antibody; YVH1 protein tyrosine phosphatase ortholog antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Fusion protein of Human DUSP12
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:5000
WB	1:200-1:1000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates.
基因功能參考文獻：
1. Results from a study on gene variability markers in early-stage human embryos shows that DUSP12 is a putative variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
2. A significant decrease in DUSP12 expression in hypertrophic hearts and cardiomyocytes. PMID: 27702885
3. These results propagate a role for dual specificity phosphatases at RNP particles and suggest that hYVH1 may affect a variety of fundamental cellular processes by regulating messenger ribonucleoprotein (mRNP) dynamics. PMID: 27856639
4. hYVH1 is a novel modulator of cell cycle progression mediated by a phosphorylation site located at the C-terminal end of the zinc-binding domain PMID: 21521943
5. propose that the BRC repeats in BRCA2 cooperate in a partially redundant but reinforcing manner to ensure a high probability of RAD51 filament formation PMID: 21556130
6. these data suggests common SNPs within DUSP12-ATF6 locus may not play a major role in glucose metabolism in the Chinese. PMID: 21211013
7. tudies confirmed elevated expression of three target antigens RAB38, TBCE, and DUSP12 in CML. PMID: 20103624
8. Our data suggest that sequences in or upstream of DUSP12 may contribute to type 2 diabetes susceptibility, but the lack of replication suggests a small effect size. PMID: 16936214
9. hYVH1 is a novel cell survival phosphatase that co-operates with Hsp70 to positively affect cell viability in response to cellular insults. PMID: 18973475
10. Data determined that hYVH1 forms intramolecular disulfide bonds at the catalytic cleft as well as within the zinc binding domain to avoid irreversible inactivation during severe oxidative stress. PMID: 19567874
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亞細胞定位：

Nucleus. Cytoplasm, cytosol.
蛋白家族：

Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
組織特異性：

Ubiquitous, highest expression in spleen, testis, ovary, and peripheral blood leukocytes and lower expression in liver and lung.
數據庫鏈接：

HGNC: 3067

OMIM: 604835

KEGG: hsa:11266

STRING: 9606.ENSP00000356920

UniGene: Hs.416216

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