DRG1 Antibody

說明書

中文名稱：

DRG1兔多克隆抗體
貨號：

CSB-PA696333
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA696333(DRG1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA696333(DRG1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Human fetal liver tissue, Human brain tissue, 293T cells, Hela cells, Primary antibody: CSB-PA696333(DRG1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9Y295
基因名：

DRG1
別名：

Developmentally regulated GTP binding protein 1 antibody; Developmentally-regulated GTP-binding protein 1 antibody; DKFZp434N1827 antibody; DRG 1 antibody; DRG-1 antibody; DRG1 antibody; DRG1_HUMAN antibody; NEDD 3 antibody; NEDD-3 antibody; NEDD3 antibody; Neural precursor cell expressed developmentally down regulated protein 3 antibody; Neural precursor cell expressed developmentally down-regulated protein 3 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Fusion protein of Human DRG1
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions.
基因功能參考文獻：
1. DRG1 was an important protein involved in spindle checkpoint signaling, and elevated levels of DRG1 caused lung adenocarcinoma and taxol resistance. PMID: 27626498
2. DRG-1 plays an important role in melanoma cell growth and transformation, indicating that DRG1 may represent a novel target for CD4(+) T cell-mediated immunotherapy in melanoma. PMID: 25993655
3. Lerepo4 action leaves Drg1 affinity for nucleotides unaffected, feasibly favoring a switch I reorientation, mainly via the TGS domain. PMID: 23711155
4. Drg-1 is a candidate metastasis suppressor gene for prostate cancer and may serve as a useful prognostic marker. PMID: 12702552
5. our results strongly suggest functional involvement of the Drg-1 gene in suppressing the metastatic advancement of human breast cancer. PMID: 15184886
6. The tumor metastasis suppressor gene Drg-1 suppresses metastasis of prostate tumor cells by inhibiting the invasive ability of the cells via down-regulation of the expression of the ATF3 gene. PMID: 17178897
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亞細胞定位：

Nucleus. Cytoplasm. Note=The DRG1-ZC3H15/DFRP1 complex associates with polysomes.
蛋白家族：

TRAFAC class OBG-HflX-like GTPase superfamily, OBG GTPase family
組織特異性：

High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes.
數據庫鏈接：

HGNC: 3029

OMIM: 603952

KEGG: hsa:4733

STRING: 9606.ENSP00000329715

UniGene: Hs.115242

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