DR1 Antibody
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中文名稱：DR1兔多克隆抗體
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貨號：CSB-PA007175GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：DR1
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別名：Down regulator of transcription 1 antibody; Down regulator of transcription 1 TBP binding antibody; Down-regulator of transcription 1 antibody; down-regulator of transcription 1; TBP-binding (negative cofactor 2) antibody; DR 1 antibody; Dr1 antibody; Dr1 protein antibody; NC 2 antibody; NC2 antibody; NC2 beta antibody; NC2-beta antibody; NC2B_HUMAN antibody; Negative co factor 2 antibody; Negative cofactor 2 antibody; Negative cofactor 2 beta antibody; Negative cofactor 2-beta antibody; Protein Dr1 antibody; TATA binding protein associated phosphoprotein antibody; TATA box/binding protein associated phosphoprotein DR1 antibody; TATA-binding protein-associated phosphoprotein antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human DR1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
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基因功能參考文獻：
- results suggest that DR1 are expressed in the osteosarcoma cells and inhibit the proliferation of osteosarcoma cells by the down-regulation of the ERK1/2 and PI3K-Akt pathways. PMID: 28181134
- Knockdown of DR1 resulted in reductions of viral RNA and protein production, demonstrating that DR1 acts as a positive host factor in influenza A virus replication. PMID: 25589657
- Basal core promoters control the equilibrium between negative cofactor 2 and preinitiation complexes in human cells. PMID: 20230619
- The physiological functions of human Dr1 include regulation of polymerase III transcription. PMID: 19965767
- NC2 controls TBP binding and maintenance on DNA that is largely independent of a canonical TATA sequence PMID: 15574413
- the initiator core promoter element antagonizes repression of TATA-directed transcription by negative cofactor NC2 PMID: 17584739
- Data show that NC2beta is specifically involved in neuroblastoma pathogenesis and may be considered a new neuroblastoma biomarker. PMID: 18538002
- ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein PMID: 18838386
- heterodimerization with NC2alpha masks the nuclear localization signal in NC2beta, which prevents nuclear export of the NC2 complex PMID: 19204005
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亞細(xì)胞定位：Nucleus.
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蛋白家族：NC2 beta/DR1 family
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數(shù)據(jù)庫鏈接：
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