DPY19L2 Antibody, FITC conjugated
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中文名稱：DPY19L2兔多克隆抗體, FITC偶聯(lián)
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貨號：CSB-PA757514LC01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) DPY19L2 Polyclonal antibody
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Uniprot No.：
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基因名：DPY19L2
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別名：DPY19L2 antibody; UNQ3127/PRO10284 antibody; Probable C-mannosyltransferase DPY19L2 antibody; EC 2.4.1.- antibody; Dpy-19-like protein 2 antibody; Protein dpy-19 homolog 2 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Probable C-mannosyltransferase DPY19L2 protein (599-749AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. Required during spermatogenesis for sperm head elongation and acrosome formation.
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基因功能參考文獻(xiàn)：
- Low PLCZ1 expression is associated with globozoospermia with DPY19L2 deletion. PMID: 29339016
- provide new evidence, on the one hand, for a severe lack of maturation of the NL, and on the other hand, for dramatic modifications in the location of chromatin-related NL partners in DPY19L2-deleted spermatozoa PMID: 28882431
- Patients presenting with a monomorphic teratozoospermia such as globozoospermia or macrospermia with more than 85% of the spermatozoa presenting this specific abnormality have been analyzed permitting to identify several key genes for spermatogenesis such as AURKC and DPY19L2. PMID: 27779748
- Among Tunisian patients with globozoospermia, 8 DPY19L2 haplotypes were found. 61.1% were homozygous for a DPY19L2 deletion. A new splice-site mutation at the junction exon-intron 16 [c.1579_1580+4delAGGTAAinsTCAT] was found in 1 patient. PMID: 26516168
- The DPY19L2 mutations are the major cause of globozoospermia. PMID: 23512994
- Analysis of public databases at the DPY19L2 locus paradoxically revealed that, in the general population, duplications were approximately three times as frequent as deletions. PMID: 23555282
- DPY19L2 is the major gene responsible for globozoospermia and enlarges the spectrum of possible mutations in the gene. PMID: 22653751
- identification of DPY19L2 deletions and point mutations in European patients shows that globozoospemia caused by a molecular defect of DPY19L2 can be expected in individuals from any ethnic background PMID: 22627659
- Patients with globozoospermia have a homozygous deletion of DPY19L2. PMID: 21397064
- The relocation of the gene DPY19L2 within a set of low copy repeats. PMID: 16526957
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相關(guān)疾病：Spermatogenic failure 9 (SPGF9)
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亞細(xì)胞定位：Membrane; Multi-pass membrane protein.
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蛋白家族：Dpy-19 family
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組織特異性：Widely expressed with high expression in testis. Not detectable in ejaculated sperm (at protein level).
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