DPP8 Antibody

說明書

中文名稱：

DPP8兔多克隆抗體
貨號：

CSB-PA744278ESR1HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA744278ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA744278ESR1HU at dilution of 1:100
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) DPP8 Polyclonal antibody
Uniprot No.：

Q6V1X1
基因名：

DPP8
別名：

Dipeptidyl peptidase 8 antibody; Dipeptidyl peptidase IV-related protein 1 antibody; Dipeptidyl peptidase VIII antibody; Dipeptidylpeptidase 8 antibody; DP8 antibody; DPP VIII antibody; Dpp8 antibody; DPP8_HUMAN antibody; DPRP-1 antibody; DPRP1 antibody; EC 3.4.14.5 antibody; MSTP141 antibody; Prolyl dipeptidase DPP8 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Dipeptidyl peptidase 8 protein (10-230AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (Probable). Acts as an inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis: inhibits pyroptosis by preventing activation of NLRP1 and CARD8 via an unknown mechanism.
基因功能參考文獻：
1. The DPP8 expressing cell model system is a very useful and promising system for investigating the selectivity and associated toxicity of DPP4 inhibitors on DPP8. PMID: 25464020
2. The SUMO1-E67 interacting loop peptide is an allosteric inhibitor of the dipeptidyl peptidases 8 and 9. PMID: 24072711
3. Suggest roles for DPP8 and DPP9 in lymphocyte activation and apoptosis and in hepatocytes during liver disease pathogenesis. PMID: 23704821
4. DPP8 was found in macrophages of carotid atherosclerotic plaque and may play a role in disease progression. PMID: 23608773
5. analysis of dipeptidyl peptidases 8 and 9 reveals that they may have compensatory roles PMID: 23519473
6. this study demonstrates for the first time that DP8 and DP9 are expressed in breast and ovarian carcinoma cell lines PMID: 22736146
7. Data identify modification points in the topology of a representative DPP8/9-inhibitor, capable of rendering selectivity for DPP8 over DPP9. PMID: 21711053
8. This is the first study to demonstrate the presence of DP8 in chronic lymphocytic leukemia (CLL) and the upregulation of DP8 mRNA in CLL. PMID: 20534982
9. DPP8 and DPP9 prevail over canonical DPP-IV/CD26 and FAPalpha in all examined meningioma patients PMID: 20043068
10. cells overexpressing DP8 exhibit behavioral changesin the presence of ECM components; these effects were independent of enzyme activity PMID: 16700509
11. Dipeptidyl peptidase 8 and dipeptidyl peptidase 9 influence cell-extracellular matrix interactions, and thus may regulate tissue remodeling. PMID: 16704418
12. study has identified the residues absolutely required for the optimal activity of DPP8 and its unique substrate specificity PMID: 17040910
13. DP8 cleavage of the N-terminal two residues of IP10 (CXCL10), ITAC (CXCL11) and SDF-1 (CXCL12), is reported. PMID: 18275857
14. DP8 and DP9 tissue and cellular expression PMID: 19581630
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亞細胞定位：

Cytoplasm.
蛋白家族：

Peptidase S9B family, DPPIV subfamily
組織特異性：

Ubiquitously expressed, with highest levels in testis, placenta, prostate, muscle and brain.
數據庫鏈接：

HGNC: 16490

OMIM: 606819

KEGG: hsa:54878

STRING: 9606.ENSP00000339208

UniGene: Hs.458609

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