DPH1 Antibody, Biotin conjugated

說明書

中文名稱：

DPH1兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA871625LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) DPH1 Polyclonal antibody
Uniprot No.：

Q9BZG8
基因名：

DPH1
別名：

Candidate tumor suppressor in ovarian cancer 1 antibody; Diphthamide biosynthesis protein 1 antibody; Diphthamide biosynthesis protein 2 homolog like 1 antibody; Diphthamide biosynthesis protein 2 homolog-like 1 antibody; Diphthamide biosynthesis protein 2 like antibody; Diphthamide biosynthesis protein 2-like antibody; Diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces) like 1 antibody; Diptheria toxin resistance protein required for diphthamide biosynthesis like 1 antibody; DPH like 1 (S. cerevisiae) antibody; DPH like 1 antibody; DPH-like 1 antibody; DPH1 antibody; DPH1 homolog (S. cerevisiae) antibody; DPH1 homolog antibody; DPH1_HUMAN antibody; DPH2 like 1 antibody; DPH2-like 1 antibody; DPH2L antibody; DPH2L1 antibody; FLJ33211 antibody; HsDph1 antibody; Ovarian cancer associated gene 1 antibody; Ovarian cancer associated gene 1 protein antibody; Ovarian cancer-associated gene 1 protein antibody; Ovarian tumor suppressor candidate 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 protein (192-318AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers. Plays a role in embryonic growth, organogenesis and postnatal survival.
基因功能參考文獻：
1. novel homozygous DPH1 mutation causes intellectual disability and unique craniofacial features PMID: 29410513
2. We used WES to identify novel compound heterozygous mutations in DPH1 (c.289delG, p.Glu97Lysfs*8 and c.491T>C, p.Leu164Pro) in a patient from a nonconsanguineous family presenting with intellectual disability, a short stature, craniofacial abnormalities, and external genital abnormalities. PMID: 29362492
3. DPH1 functions as an oncogene in CRC and can be negatively modulated by miR-218-5p to promote CRC tumourigenesis. PMID: 29145210
4. Results identified a second homozygous missense variant in DPH1, seen in four members of a founder population, and associated with autosomal recessive intellectual disability with short stature, craniofacial, and ectodermal anomalies. PMID: 26220823
5. Methylation of the DPH1 promoter causes immunotoxin resistance in acute lymphoblastic leukemia. PMID: 24070652
6. OVCA1 could inhibit the proliferation of ovarian cancer cells by p16/cyclin D1 pathway, but not by NF-kappaB PMID: 21487939
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相關疾病：

Developmental delay with short stature, dysmorphic features, and sparse hair (DEDSSH)
亞細胞定位：

Nucleus. Cytoplasm. Note=Punctate, primarily perinuclear localization.
蛋白家族：

DPH1/DPH2 family, DPH1 subfamily
組織特異性：

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, mammary gland, colon, small intestine, testis and ovary. Reduced expression in primary breast and ovarian tumors.
數據庫鏈接：

HGNC: 3003

OMIM: 603527

KEGG: hsa:1801

STRING: 9606.ENSP00000263083

UniGene: Hs.513856

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