DOCK9 Antibody
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中文名稱：DOCK9兔多克隆抗體
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貨號：CSB-PA007105GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：DOCK9
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別名：Cdc42 guanine nucleotide exchange factor zizimin 1 antibody; Cdc42 guanine nucleotide exchange factor zizimin-1 antibody; Dedicator of cytokinesis protein 9 antibody; DKFZp686C11110 antibody; DKFZp686D2047 antibody; DKFZp686N04132 antibody; DOCK 9 antibody; DOCK9 antibody; DOCK9_HUMAN antibody; FLJ16744 antibody; FLJ44528 antibody; FLJ45282 antibody; FLJ45601 antibody; KIAA1058 antibody; KIAA1085 antibody; ZIZ1 antibody; Zizimin1 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human DOCK9
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC,IF
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.
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基因功能參考文獻：
- c.2262A>C substitution in DOCK9 leads to a splicing aberration. However, because the mutation effect was observed in vitro, a definitive relationship between DOCK9 and KTCN phenotype could not be established. PMID: 26641546
- Studies indicate that that many of the mechanistic principles of the exchange process are conserved in the DOCK9-catalyzed reaction. PMID: 19809089
- Sequence comparison combined with mutational analysis identified a new domain, which we named CZH2, that mediates direct interaction with Cdc42 PMID: 12172552
- DOCK9 contributes to both risk and increased illness severity in bipolar disorder. PMID: 17728666
- novel functions for the N-terminal region of zizimin1. PMID: 17935486
- DOCK2 and DOCK9 specifically recognize Rac2 and Cdc42 through their switch 1 as well as beta2-beta3 regions and the mode of recognition via switch 1 appears to be conserved among diverse Rac-specific DHR-2 GEFs PMID: 18056264
- interaction between Smad2/3 and the Cdc42 guanine nucleotide exchange factor, Zizimin1, in response to TGF-beta1 PMID: 18729074
- through structural analysis of DOCK9-Cdc42 complexes, we identify a nucleotide sensor within the alpha10 helix of the DHR2 domain that contributes to release of guanine diphosphate (GDP) and then to discharge of the activated GTP-bound Cdc42 PMID: 19745154
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亞細胞定位：Endomembrane system.
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蛋白家族：DOCK family
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組織特異性：Widely expressed, with highest expression in heart and placenta. Expressed at intermediate level in kidney, brain, lung and skeletal muscle.
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數據庫鏈接：
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